Study on the Relationship between Serum Irisin,DJ-1 and Recurrence after TURBT in Patients with Non-Muscle Invasive Bladder Cancer
Objective:To study the relationship between serum irisin(Irisin),mitogen-dependent oncogene(DJ-1)and recurrence after transurethral resection of bladder tumor(TURBT)in patients with non-muscle invasive bladder cancer(NMIBC).Methods:180 NMIBC patients who underwent TURBT in our hospital from January 2020 to January 2022 were selected as the study subjects.All patients were treated with TURBT,and the levels of serum Irisin and DJ-1 were detected and compared between two groups before operation.The clinical data of NMIBC patients were collected,and the influencing factors of recurrence after TURBT in NMIBC patients were analyzed by established multivariate Logistic regression model.The predictive value of serum Irisin and DJ-1 for recurrence after TURBT in NMIBC patients was evaluated by receiver operating characteristic(ROC)curve.Results:Among the 180 patients,42 cases recurred,accounting for 23.33％,and were included in recurrence group.There were 138 cases of non-recurrence,accounting for 76.67％,which were included in non-recurrence group.The serum Irisin level in recurrence group was lower than that in non-recurrence group,while the DJ-1 level was higher than that in non-recurrence group(P＜0.05).The proportion of patients with clinical TNM stage Tl,organizational classification into poorly differentiated and multiple tumors in recurrence group was higher than that in non-recurrence group(P＜0.05).Multivariate Logistic regression analysis showed that,clinical TNM stage was T1 stage,organizational classification was poorly differentiated,the number of tumors was multiple,serum Irisin decreased and DJ-1 increased were risk factors for postoperative recurrence.The results of ROC analysis showed that,the combined detection of serum Irisin and DJ-1 had the highest predictive value for recurrence after TURBT in NMIBC patients.The area under the curve(AUC)of the combined detection was 0.858,the sensitivity was 94.32％,and the specificity was 79.34％,which was higher than that of each index alone.Conclusion:The decrease of serum Irisin and the increase of DJ-1 are relate to the recurrence of NMIBC patients after TURBT,and the combine detection of the two has a high predictive value for the recurrence after TURBT.
IrisinMitogen-dependent oncogeneNon-muscle invasive bladder cancerTransurethral resection of bladder tumorRecurrence after operationPredictive value
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