Study on the Relationship between Serum Total IgE,CCSP,TIM-3,Severity of Disease and Prognosis in Children with Mycoplasma Pneumoniae Pneumonia
Objective:To investigate the relationship between serum total immunoglobulin E(IgE),Clara cell secretory protein(CCSP),T cell immunoglobulin mucin molecule 3(TIM-3),severity of disease and prognosis in children with mycoplasma pneumoniae pneumonia(MPP).Methods:182 children with MPP admitted to Shanxi Children's Hospital from August 2021 to August 2023 were selected as observation group,children were divided into mild group and severe group according to the condition of children with MPP,and children were divided into good prognosis group and poor prognosis group according to the prognosis of children with MPP after treatment.Another 100 healthy children who underwent physical examination during the same period were included in control group.The levels of serum total IgE,CCSP and TIM-3 were detected,the influencing factors of poor prognosis in children with MPP were analyzed by univariate and multivariate Logistic regression analysis.Results:The serum total IgE and TIM-3 in observation group were higher than those in control group,and CCSP was lower than that in control group(P＜0.05).The serum total IgE and TIM-3 in severe group were higher than those in mild group,and CCSP was lower than that in mild group(P＜0.05).Among the 182 children with MPP,59 had poor prognosis,with a poor prognosis rate of 32.42％.The serum total IgE and TIM-3 in poor prognosis group were higher than those in good prognosis group,and CCSP was lower than that in good prognosis group(P＜0.05).Univariate analysis showed that the level of C-reactive protein(CRP),proportion of severe cases,duration of fever,clinical pulmonary infection score(CPIS)and course of disease in poor prognosis group were higher than those in good prognosis group(P＜0.05).Multivariate Logistic regression analysis showed that,long course of disease,high CPIS score,elevated serum total IgE,TIM-3 and decreased CCSP were risk factors for poor prognosis in children with MPP(P＜0.05).Conclusion:The abnormal expression of serum total IgE,CCSP and TIM-3 in children with MPP are closely relate to the severity of the disease,the increase of serum total IgE and TIM-3,the decrease of CCSP,the long course of disease and the high CPIS score are risk factors for poor prognosis in children with MPP.
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