The Clinical Significance of Serum γ-glutamyltranspeptidase and Galactin-3 in Patients with Rheumatoid Arthritis Complicated with Heart Failure
Objective:To investigate the clinical significance of serum γ-glutamyltranspeptidase and galactolectin 3 in patients with rheumatoid arthritis complicated with heart failure.Methods:300 patients with rheumatoid arthritis who came to our hospital from January 2019 to December 2023 were selected,and 150 healthy people who came to our hospital for physical examination were selected as the control group.According to whether the patients were combined with heart failure,300 patients were divided into the heart failure group and the non-heart failure group.The rheumatoid arthritis patients were admitted to the hospital in the morning of the next day,and the control group were tested for serum γ-glutamyltranspeptidase and galactin-3 levels by fasting blood sampling in the morning of the physical examination day.The levels of serum γ-glutamyltranspeptidyase and galactin-3 in patients with heart failure group,non-heart failure group and control group,patients with heart failure group Ⅱ,Ⅲ,Ⅳ,and patients with good prognosis and poor prognosis were compared.ROC curve was used to analyze the diagnostic and prognostic value of serum γ-glutamyltranspeptidase,galactin-3 and their combination in rheumatoid arthritis complicated with heart failure.Results:The levels of serum γ-glutamyltranspeptidase and galactin-3 were higher in the heart failure group than in the non-heart failure group than in the control group(P＜0.05).Among the 98 patients with heart failure,41 cases had grade Ⅱ,39 cases had grade Ⅲ,and 18 cases had grade Ⅳ.Serum levels of γ-glutamyltranspeptidase and galactin-3 were as follows:Grade Ⅳ＞grade Ⅲ＞grade Ⅱ,and pair-to-pair comparison between groups had statistical significance(P＜0.05).Of 98 patients with heart failure,76 had good prognosis and 22 had poor prognosis.Serum levels of γ-glutamyltranspeptidase and galactin-3 in patients with good prognosis were significantly lower than those in patients with poor prognosis(P＜0.05).Serumγ-glutamyltranspeptidase,galactin-3,and their combination can be used in the diagnosis and prognosis of rheumatoid arthritis complicated with heart failure,and the combination of the two indexes has higher diagnostic value than a single index(P＜0.05).Conclusion:The serum y-glutamyltransferase combined with galactin-3 can be used for the diagnosis and prognosis of rheumatoid arthritis complicated with heart failure,and they are closely related to the severity of heart failure.
γ-glutamyltranspeptidaseGalectin-3Rheumatoid arthritis with heart failure
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