Relationship between Prognostic Nutritional Index,D-Dimer/Fibrinogen Ratio and Malignant Degree and Postoperative Recurrence in Glioma Patients
Objective:To investigate the relationship between prognostic nutritional index(PNI),D-dimer/fibrinogen ratio(DFR)and malignant degree and postoperative recurrence in glioma patients.Methods:132 glioma patients admitted to our hospital from June 2019 to June 2022 were selected,the patients were divided into low-level group(grade Ⅰ+Ⅱ,97 cases)and high-level group(grade Ⅲ+Ⅳ,35 cases)according to the World Health Organization(WHO)classification.All patients underwent tumor resection,serum albumin,lymphocyte count,D-dimer and fibrinogen levels were measured before operation,PNI and DFR were calculated,postoperative recurrence was followed up,the relationship between PNI and DFR and postoperative recurrence of glioma patients was analyzed.Results:PNI in high-level group was lower than that in low-level group(P＜0.05),and DFR was higher than that in low-level group(P＜0.05).After a median follow-up of 25(8-44)months,2 cases were lost to follow-up,and 33 cases recurred during the follow-up period.PNI in recurrence group was lower than that in non-recurrence group(P＜0.05),and DFR was higher than that in non-recurrence group(P＜0.05).Multivariate Logistic regression showed that high WHO grade,high DFR were risk factors for postoperative recurrence of glioma patients(P＜0.05),and high PNI was a protective factor(P＜0.05).Conclusion:Preoperative PNI decrease and DFR increase in patients with high WHO grade and postoperative recurrence of glioma,increase DFR is a risk factor for postoperative recurrence,and increase PNI is a protective factor.
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