预后营养指数、D-二聚体/纤维蛋白原比值与脑胶质瘤患者恶性程度和术后复发的关系
Relationship between Prognostic Nutritional Index,D-Dimer/Fibrinogen Ratio and Malignant Degree and Postoperative Recurrence in Glioma Patients
褚夫政 1徐义强 1汪敏行 1邓李轶 1高文昌1
作者信息
- 1. 徐州医科大学附属医院神经外科 江苏徐州 221000
- 折叠
摘要
目的:探讨预后营养指数(PNI)、D-二聚体/纤维蛋白原比值(DFR)与脑胶质瘤患者恶性程度和术后复发的关系.方法:选择2019年6月至2022年6月我院收治的132例脑胶质瘤患者,根据世界卫生组织(WHO)分级将患者分为低级别组(Ⅰ+Ⅱ级,97例)和高级别组(Ⅲ+Ⅳ级,35例).所有患者接受肿瘤切除术,术前检测血清白蛋白、淋巴细胞计数、D-二聚体、纤维蛋白原水平,计算PNI和DFR,术后随访统计复发情况,分析PNI和DFR与脑胶质瘤患者术后复发的关系.结果:高级别组PNI低于低级别组(P＜0.05),DFR高于低级别组(P＜0.05).术后中位随访25(8-44)月,失访2例,随访期间复发33例.复发组PNI低于未复发组(P＜0.05),DFR高于未复发组(P＜0.05).多因素Logistic回归显示WHO分级高级别,高DFR是脑胶质瘤患者术后复发的危险因素(P＜0.05),高PNI是保护因素(P＜0.05).结论:高WHO分级和术后复发的脑胶质瘤患者术前PNI降低,DFR升高,DFR升高是其术后复发的危险因素,PNI升高是保护因素.
Abstract
Objective:To investigate the relationship between prognostic nutritional index(PNI),D-dimer/fibrinogen ratio(DFR)and malignant degree and postoperative recurrence in glioma patients.Methods:132 glioma patients admitted to our hospital from June 2019 to June 2022 were selected,the patients were divided into low-level group(grade Ⅰ+Ⅱ,97 cases)and high-level group(grade Ⅲ+Ⅳ,35 cases)according to the World Health Organization(WHO)classification.All patients underwent tumor resection,serum albumin,lymphocyte count,D-dimer and fibrinogen levels were measured before operation,PNI and DFR were calculated,postoperative recurrence was followed up,the relationship between PNI and DFR and postoperative recurrence of glioma patients was analyzed.Results:PNI in high-level group was lower than that in low-level group(P＜0.05),and DFR was higher than that in low-level group(P＜0.05).After a median follow-up of 25(8-44)months,2 cases were lost to follow-up,and 33 cases recurred during the follow-up period.PNI in recurrence group was lower than that in non-recurrence group(P＜0.05),and DFR was higher than that in non-recurrence group(P＜0.05).Multivariate Logistic regression showed that high WHO grade,high DFR were risk factors for postoperative recurrence of glioma patients(P＜0.05),and high PNI was a protective factor(P＜0.05).Conclusion:Preoperative PNI decrease and DFR increase in patients with high WHO grade and postoperative recurrence of glioma,increase DFR is a risk factor for postoperative recurrence,and increase PNI is a protective factor.
关键词
脑胶质瘤/预后营养指数/D-二聚体/纤维蛋白原比值/恶性程度/复发Key words
Glioma/Prognostic nutritional index/D-dimer/fibrinogen ratio/Malignant degree/Recurrence引用本文复制引用
基金项目
江苏省自然科学基金面上项目(BK20181152)
出版年
2024
NETL
NSTL
万方数据