Analysis of Differences in Serum Vitamin A,IGF-1 and SOCS1 mRNA Levels in Different Types of Pediatric Respiratory Tract Infections and Factors Affecting Prognosis
Objective:To investigate the difference of serum vitamin A,IGF-1 and SOCS1 mRNA levels and prognostic factors in children with different types of respiratory tract infection.Methods:80 children with respiratory tract infections who came to our hospital from January 2021 to December 2023 were selected and divided into pneumonia group(38 cases)and upper respiratory tract infection group(42 cases)according to the types of infection.The general data,laboratory test results of blood routine,serum vitamin A,IGF-1 and SOCS1mRNA levels in two groups were compared,and the prognosis in two groups were analyzed.The influencing factors of good prognosis and poor prognosis were compared,and the predictive value of serum vitamin A,IGF-1 and SOCS1mRNA levels on the prognosis of children with pneumonia was analyzed.Results:The age and serum lymphocytes of pneumonia group were significantly lower than those of upper respiratory tract infection group,the proportion of fever and cough was higher than that of upper respiratory tract infection group,and the proportion of sore throat was lower than that of upper respiratory tract infection group(P＜0.05).The levels of vitamin A and IGF-1 in the pneumonia group were lower than those in the upper respiratory tract infection group,and SOCS1 mRNA was higher than those in the upper respiratory tract infection group(P＜0.05).All 42 cases of upper respiratory tract infection were cured.Among the 38 children with pneumonia,22 cases were cured,8 cases were effective,and 8 cases were ineffective.The cured+effective group was regarded as the good prognosis group,with a total of 30 cases,accounting for 78.95％(30/38),and 8 cases with poor prognosis,accounting for 21.95％(8/38).Multivariate Logsitic regression analysis showed that age 1-6 years old,decreased vitamin A level,decreased IGF-1 level,and increased SOCS1 mRNA level were risk factors for poor prognosis in children with pneumonia(P＜0.05).Vitamin A and IGF-1 can be used to predict the prognosis of pediatric pneumonia,with AUC＞0.80,P＜0.05.SOCS1 mRNA has poor diagnostic efficacy for the prognosis of pediatric pneumonia,P＞0.05.Conclusion:Compared with children with upper respiratory tract infection,the serum vitamin A and IGF-1 are significantly reduced,and the SOCS1 mRNA level is significantly increased.Vitamin A and IGF-1 can be used to judge the prognosis of pediatric pneumonia.Age 1-6 years,vitamin A,IGF-1 and SOCS1 mRNA levels are risk factors for poor prognosis of children with pneumonia.
NETL
NSTL
万方数据
