Study on the Relationship between Serum SAA,IL-17,LCN2 Levels and the Severity of Disease in Patients with Chronic Spontaneous Urticaria
Objective:To investigate the relationship between serum amyloid A(SAA),interleukin-17(IL-17),lipid carrier protein 2(LCN2)levels and the severity of disease in patients with chronic spontaneous urticaria(CSU).Methods:152 CSU patients(CSU group)and 130 healthy subjects(control group)admitted to our hospital from January 2021 to December 2023 were selected.The levels of serum SAA,IL-17 and LCN2 in CSU group and control group were detected and compared by enzyme-linked immunosorbent assay.CSU patients were divided into mild CSU group(40 cases),moderate CSU group(65 cases)and severe CSU group(47 cases)according to the 7-day urticaria activity score(UAS7),the levels of serum SAA,IL-17 and LCN2 were compared in three groups.The correlation between serum SAA,IL-17,LCN2 levels and UAS7 in CSU patients was analyzed by Spearman method,the predictive value of serum SAA,IL-17,LCN2 levels on the severity of disease in CSU patients was analyzed by receiver operating characteristic(ROC)curve.Results:Compared with control group,the levels of serum SAA,IL-17 and LCN2 in CSU group were increased(P＜0.05).The levels of serum SAA,IL-17 and LCN2 in mild CSU group,moderate CSU group and severe CSU group increased in turn(P＜0.05).Serum SAA,IL-17 and LCN2 levels were positively correlated with UAS7 in CSU patients(r=0.537,0.616,0.573,all P＜0.001).The area under the curve(AUC)of combined detection of serum SAA,IL-17 and LCN2 levels in predicting moderate CSU and severe CSU were 0.914 and 0.911 respectively,which were greater than 0.769,0.789,0.777 and 0.770,0.807,0.779 predicted by serum SAA,IL-17 and LCN2 levels alone(P＜0.05).Conclusion:The increase of serum SAA,IL-17 and LCN2 levels are relate to the severity of disease in CSU patients,the combine detection of serum SAA,IL-17 and LCN2 levels is more effective in predicting the severity of disease in CSU patients.
Chronic spontaneous urticariaSAAIL-17LCN2Severity of diseasePredictive value
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