Comparison of the Efficacy of Thoracoscopic Assisted Anterior Mediastinal Tumor Resection Via Subxiphoid and Lateral Thoracic Approach and its Effects on Stress Response and Inflammatory Factors
Objective:To compare the application effects of thoracoscopic assisted anterior mediastinal tumor resection by lateral thoracic approach or subxiphoid approach.Methods:According to the random number table method,115 patients undergoing thoracoscopic assisted anterior mediastinal tumor resection were divided into group A(n=57,lateral thoracic approach)and group B(n=58,subxiphoid approach).The perioperative related indexes,stress response indexes and inflammatory factors were compared between two groups,and the occurrence of postoperative complications was observed.Results:Compared with group A,group B had longer operation time,less intraoperative blood loss and postoperative drainage volume,shorter postoperative hospital stay and drainage tube indwelling time(P＜0.05).1 day after operation,neuropeptide Y(NPY),5-hydroxytryptamine(5-HT),substance P(SP)and prostaglandin E2(PGE2)in two groups increased,but group B were lower than those of group A(P＜0.05).1 day after operation,C-reactive protein(CRP),white blood cell count(WBC)and neutrophils increased in two groups,but group B were lower than those of group A(P＜0.05).The total incidence of complications in group A was 12.28％,and that in group B was 6.90％,there was no difference between two groups(P＞0.05).Conclusion:During thoracoscopic assisted anterior mediastinal tumor resection,although the subxiphoid approach takes longer than the lateral thoracic approach,which can reduce intraoperative injury,reduce stress response and inflammatory response,and promote postoperative recovery.
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