摘要
目的:探讨分化簇64(CD64)指数、系统免疫炎症指数(SII)、C反应蛋白/白蛋白(CRP/Alb)比值与肝癌肝部分切除术(PR)患者术后感染的关系.方法:选取2021年1月～2023年10月在我院行PR的肝癌患者300例,根据是否发生术后感染分为感染组和无感染组,计算CD64指数、SII、CRP/Alb比值.采用多因素Logistic回归分析肝癌PR患者术后感染的因素,受试者工作特征(ROC)曲线分析CD64指数、SII、CRP/Alb比值对肝癌PR患者术后感染的预测价值.结果:300例肝癌PR患者术后感染发生率为21.33％(64/300).与无感染组比较,感染组CD64指数、SII、CRP/Alb比值升高(P＜0.05).多因素Logistic回归分析显示糖尿病、术中输血、引流管放置时间≥ 7d和CD64指数、SII、CRP/Alb比值升高为肝癌PR患者术后感染的独立危险因素(P＜0.05).CD64指数、SII、CRP/Alb比值联合预测肝癌PR患者术后感染的曲线下面积为0.910,大于CD64指数、SII、CRP/Alb比值单独预测的0.790、0.778、0.776.结论:CD64指数、SII、CRP/Alb比值升高为肝癌PR患者术后感染的独立危险因素,CD64指数、SII、CRP/Alb比值联合预测肝癌PR患者术后感染的价值较高.
Abstract
Objective:To investigate the relationship between cluster of differentiation 64(CD64)index,systemic immune inflammation index(SII),C-reactive protein/albumin(CRP/Alb)ratio and postoperative infection in patients with partial hepatectomy(PR)for liver cancer.Methods:300 patients with liver cancer who underwent PR in our hospital from January 2021 to October 2023 were selected and divided into infection group and non-infection group according to whether postoperative infection occurred,the CD64 index,SII and CRP/Alb ratio were calculated.The factors of postoperative infection in patients with liver cancer PR were analyzed by multivariate Logistic regression analysis,the predictive value of CD64 index,SII and CRP/Alb ratio for postoperative infection in patients with liver cancer PR were analyzed by receiver operating characteristic(ROC)curve.Results:The incidence of postoperative infection in 300 patients with liver cancer PR was 21.33％(64/300).Compared with non-infected group,the CD64 index,SII and CRP/Alb ratio in infected group increased(P＜0.05).Multivariate Logistic regression analysis showed that diabetes mellitus,intraoperative blood transfusion,drainage tube placement time ≥ 7 d and elevated CD64 index,SII,CRP/Alb ratio were independent risk factors for postoperative infection in patients with liver cancer PR(P＜0.05).The area under the curve of CD64 index,SII and CRP/Alb ratio in predicting postoperative infection of PR patients with liver cancer was 0.910,which was greater than 0.790,0.778 and 0.776 predicted by CD64 index,SII and CRP/Alb ratio alone(P＜0.05).Conclusions:The increase of CD64 index,SII and CRP/Alb ratio are independent risk factor for postoperative infection in PR patients with liver cancer,the combination of CD64 index,SII and CRP/Alb ratio has higher value in predicting postoperative infection in PR patients with liver cancer.
基金项目
陕西省自然科学基础研究计划项目(2022JQ-921)
NETL
NSTL
万方数据