Correlation Study of Serum CRP,MT,and IGF-1 with Oxidative Stress Indexes and Cognitive Function in Patients with First-Episode Untreated Schizophrenia
Objective:To study the correlation between serum C-reactive protein(CRP),melatonin(MT),insulin-like growth factor-1(IGF-1)and oxidative stress indexes and cognitive function in patients with first-episode untreated schizophrenia(SP).Methods:140 patients with first-episode untreated SP who were treated in Xuzhou Oriental Hospital Affiliated to Xuzhou Medical University from January 2021 to June 2023 were selected as observation group,the patients were divided into high score group(≥ 70 points)with 57 cases and low score group(＜70 points)with 83 cases according to the positive and negative symptom scale(PANSS)score.Another 140 volunteers who received physical examination in our hospital during the same period were selected as control group.Serum oxidative stress indexes,CRP,MT and IGF-1 levels were detected,and patients'cognitive dysfunction was evaluated by MATRICS cognitive assessment system(MCCB)score.The correlation between serum CRP,MT,IGF-1 and PANSS score,serum oxidative stress index,MCCB score and total score was analyzed.Results:Serum CRP in observation group was higher than that in control group,and MT and IGF-1 were lower than those in control group(P＜0.05).The serum CRP in high score group was higher than that in low score group,and the MT and IGF-1 were lower than those in low score group(P＜0.05).Serum SOD and GSH-Px in high score group were lower than those in low score group,while NO was higher than that in low score group(P＜0.05).The MCCB scores and total scores in high score group were lower than those in low score group,and the PANSS score was higher than that in low score group(P＜0.05).Pearson correlation showed that,serum CRP was positively correlated with PANSS score and NO,and negatively correlated with SOD,GSH-Px and MCCB scores and total scores(P＜0.05).Serum MT and IGF-1 were negatively correlated with PANSS score and NO,and positively correlated with SOD,GSH-Px and MCCB scores and total score(P＜0.05).Conclusion:The level of serum CRP in patients with first-episode untreated SP increase,and the levels of MT and IGF-1 decrease,there is a significant correlation between the three and oxidative stress indicators and cognitive function.
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