Clinical Study of QTc,Tp-Tec Interval Combined with Serum BNP and Gal-3 in Predicting Ventricular Arrhythmia after Acute Myocardial Infarction
Objective:To study the clinical effect of heart rate corrected QT(QTc),heart rate corrected Tp-Te(Tp-Tec)interval combined with serum brain natriuretic peptide(BNP)and galectin-3(Gal-3)in predicting ventricular arrhythmia(VA)after acute my-ocardial infarction(AMI).Methods:182 AMI patients who were treated in Jinan People's Hospital from January to July 2023 were select-ed as study subjects.Group based on whether VA occurred during hospitalization,with 71 patients with VA as the observation group and 111 patients without VA as the control group.The levels of QTc,Tp-Tec,serum BNP and Gal-3 were detected and compared between two groups.The influencing factors of VA after AMI were analyzed by multivariate Logistic regression analysis,the predictive efficacy of QTc,Tp-Tec combine with serum BNP and Gal-3 on VA after AMI were analyzed by receiver operating characteristic(ROC)curve.Results:The levels of QTc,Tp-Tec,serum BNP and Gal-3 in observation group were higher than those in control group(P＜0.05).Multi-variate Logistic regression analysis showed that elevated QTc,Tp-Tec,BNP and Gal-3 and double/multiple vascular lesions were risk factors for VA after AMI.ROC curve analysis showed that,the combined detection of QTc,Tp-Tec,BNP and Gal-3 had the best predic-tive efficacy for VA after AMI,with AUC of 0.864,sensitivity of 92.50％,specificity of 79.83％and Youden index of 0.723.Conclusion:The levels of QTc,Tp-Tec,BNP and Gal-3 in VA patients after AMI are increase,and are risk factors for VA after AMI.The combine detection of QTc,Tp-Tec,BNP and Gal-3 has a good predictive value for VA after AMI.
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