Research of Screening for Cervical Cancer Lesions in the Application of Combined with p16 Protein HPV-DNA and TCT
Objective:To investigate the effect p16 protein combined with HPV-DNA and TCT in screening cervical cancer lesions.Methods:A retrospective analysis was conducted on 3952 suspected patients who visited a women's and children's health hospital in a certain area of Guangzhou from February 2023 to December 2023.Parallel p16 protein detection,HPV-DNA screening,Thin-prep cytologic test(TCT),and cervical cancer histopathological section(HE)identification were performed.The correlation between p16 protein immunohistochemistry,HPV-DNA typing,and TCT test results in different age groups of women was analyzed and compared.Results:The positive rate of p1 6 protein detection tended to increase with the increase in HPV-DNA screening(the difference was statistically significant,P＜0.05).p16 protein detection tended to increase with the grading of TCT diagnosis results from NILM to ASC-US,ASC-H,LSIL,HSIL,and SCC groups(the difference was statistically significant,P＜0.05).p16 protein detection tended to increase with the grading of cervical cancer histopathological sections by HE staining(the difference was statistically significant,P＜0.05).The positive rate of p16 protein detection was closely related to patient age;among the 3952 women,1836 were HPV-DNA screening positive,with a positive rate of approximately 46.46％;1528 were TCT positive,with a positive rate of approximately 38.66％;grouped by age,the onset age tended to increase after 30 years old,peaked at 41-50 years old,and decreased after 60 years old,showed an upward and downward parabolic trend with age;the onset of cervical cancer also showed a trend of younger age.Conclusion:The combination of p16 protein,HPV-DNA,and TCT improved the accuracy of cervical cancer and precancerous lesion screening.
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