Correlation Analysis of Serum Chemerin,HMGB1,PTX3 and Airway Inflammation and Th17/Treg Cell Imbalance in Children with Bronchial Asthma
Objective:To analyze the correlation between serum chemerin(Chemerin),high mobility group protein 1(HMGB1),pentraxin 3(PTX3)and airway inflammation and helper T lymphocyte 17(Th17)/regulatory T lymphocyte(Treg)cell imbalance in children with bronchial asthma.Methods:150 children with bronchial asthma admitted to Bayi Children's Hospital Affiliated to the Seventh Medical Center of General Hospital of Chinese People's Liberation Army from March 2023 to December 2023 were included,The correlation between serum chemerin,HMGB1,PTX3 and airway inflammation indexes and Th17/Treg cell imbalance was analyzed by Pearson correlation analysis.Results:The levels of serum chemerin,HMGB 1 and PTX3 in children with clinical remission,chronic duration and acute attack continued to increase(P＜0.05).FeNO and peripheral blood eosinophil counts in children with clinical remission,chronic duration,and acute exacerbation continued to increase(P＜0.05).The percentage of Th17 cells and Th17/Treg ratio in children with clinical remission,chronic persistence and acute attack continued to increase,while the percentage of Treg cells continued to decrease(P＜0.05).Pearson correlation analysis showed that,chemerin,HMGB1 and PTX3 were positively correlated with FeNO,peripheral blood eosinophil count,Th17 cell percentage and Th17/Treg ratio,but negatively correlated with Treg cell percentage(P＜0.05).Conclusion:The levels of serum chemerin,HMGB1 and PTX3 in children with bronchial asthma are abnormally increase,serum chemerin,HMGB 1 and PTX3 may be involve in the pathogenesis of bronchial asthma in children by affecting airway inflammation and Th17/Treg immune imbalance.
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