摘要
目的:观察舒敏专家联合A型肉毒毒素(BTX-A)对玫瑰痤疮患者面部症状、皮肤屏障功能及血清白细胞介素-1(IL-1)、白细胞介素-6(IL-6)和白细胞介素-37(IL-37)水平的影响.方法:按照随机数字表法将120例玫瑰痤疮患者分为对照1组、对照2组、研究组,各40例.对照1组接受BTX-A治疗,对照2组接受舒敏专家治疗,研究组接受舒敏专家联合BTX-A治疗.对比三组疗效、面部症状评分、皮肤屏障功能[经皮水分丢失量(TEWL)、油脂含量、表皮含水量,皮肤pH值]及血清IL-1、IL-6和IL-37水平.结果:研究组的临床总有效率高于对照1组和对照2组(P＜0.05).研究组治疗后毛细血管扩张、红斑、皮肤潮红、丘疹脓疱评分、TEWL、皮肤pH值和血清IL-1、IL-6、IL-37水平低于对照1组和对照2组,油脂含量、表皮含水量高于对照1组和对照2组(P＜0.05).结论:舒敏专家联合BTX-A治疗玫瑰痤疮,可有效改善患者的面部症状和皮肤屏障功能,降低血清IL-1、IL-6和IL-37水平.
Abstract
Objective:To observe the effects of shumin experts combined with botulinum toxin type A(BTX-A)on facial symptoms,skin barrier function and serum interleukin-1(IL-1),interleukin-6(IL-6)and interleukin-37(IL-37)levels in rosacea patients.Methods:120 rosacea patients were divided into control group 1,control group 2 and study group according to the random number table method,with 40 cases in each group.Control group 1 received BTX-A treatment,control group 2 received shumin expert treatment,and study group received shumin expert combined with BTX-A treatment.The efficacy,facial symptom score,skin barrier function[transcutaneous water loss(TEWL),oil content,epidermal water content,skin pH value]and serum IL-1,IL-6 and IL-37 levels were compared in three groups.Results:The total clinical effective rate in study group was higher than that in control group 1 and control group 2(P＜0.05).The scores of angiotelectasis,erythema,erubescence,papulopustule,TEWL,skin pH value and serum IL-1,IL-6 and IL-37 levels in study group were lower than those in control group 1 and control group 2 after treatment,while the oil content and epidermal water content were higher than those in control group 1 and control group 2(P＜0.05).Conclusion:Shumin experts combined with BTX-A in the treatment of rosacea,which can effectively improve the facial symptoms and skin barrier function of patients,reduce the levels of serum IL-1,IL-6 and IL-37.
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