Effects of Shumin Experts Combined with Botulinum Toxin Type A on Facial Symptoms,Skin Barrier Function and Serum IL-1,IL-6 and IL-37 Levels in Rosacea Patients
Objective:To observe the effects of shumin experts combined with botulinum toxin type A(BTX-A)on facial symptoms,skin barrier function and serum interleukin-1(IL-1),interleukin-6(IL-6)and interleukin-37(IL-37)levels in rosacea patients.Methods:120 rosacea patients were divided into control group 1,control group 2 and study group according to the random number table method,with 40 cases in each group.Control group 1 received BTX-A treatment,control group 2 received shumin expert treatment,and study group received shumin expert combined with BTX-A treatment.The efficacy,facial symptom score,skin barrier function[transcutaneous water loss(TEWL),oil content,epidermal water content,skin pH value]and serum IL-1,IL-6 and IL-37 levels were compared in three groups.Results:The total clinical effective rate in study group was higher than that in control group 1 and control group 2(P＜0.05).The scores of angiotelectasis,erythema,erubescence,papulopustule,TEWL,skin pH value and serum IL-1,IL-6 and IL-37 levels in study group were lower than those in control group 1 and control group 2 after treatment,while the oil content and epidermal water content were higher than those in control group 1 and control group 2(P＜0.05).Conclusion:Shumin experts combined with BTX-A in the treatment of rosacea,which can effectively improve the facial symptoms and skin barrier function of patients,reduce the levels of serum IL-1,IL-6 and IL-37.
Shumin expertBotulinum toxin type ARosaceaFacial symptomsSkin barrier functionIL-1IL-6IL-37
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