Clinical Significance Analysisof Serum TBIL,LDH and LTBP2 Detection in Patients with Acute Exacerbation of Idiopathic Interstitial Pneumonia
Objective:To investigate the relationship between serum total bilirubin(TBIL),lactate dehydrogenase(LDH),latent transforming growth factor beta binding protein 2(LTBP2)levels and prognosis in patients with acute exacerbation of idiopathic interstitial pneumonia(AE-IIP).Methods:102 patients with AE-IIP(AE-IIP group)admitted to our hospital from January 2018 to August 2023 were selected,patients were divided into death group(30 cases)and survival group(72 cases)according to the survival status after 3 months of follow-up.The factors of death in patients with AE-IIP were analyzed by multivariate Logistic regression.Results:Compared with survival group,the serum TBIL level in death group was decreased,and the levels of LDH and LTBP2 were increased(P＜0.05).The independent protective factors of death in patients with AE-IIP were increased dynamic diffusion lung capacity of carbon monoxide(DLCO),partial pressure of oxygen/fraction of inspired oxygen(PaO2/FiO2),and TBIL,the independent risk factors were increased LDH and LTBP2(P＜0.05).Conclusion:The decrease of serum TBIL level and the increase of LDH and LTBP2 levels in patients with AE-IIP are closely relate to the poor prognosis.
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