Study on the Relationship between Serum HMGB1,Progranulin and NK Cell Subsets and Interstitial Lung Disease in Patients with Sjogren's Syndrome
Objective:To investigate the relationship between serum high mobility group protein 1(HMGB1),progranulin(PGRN)and natural killer(NK)cell subsets and interstitial lung disease(ILD)in patients with Sjogren's syndrome(SS).Methods:89 patients with SS admitted to the Zibo 148 Hospital from September 2018 to December 2023 were selected as observation group,and 80 healthy individuals in same period were selected as control group.The correlation between serum HMGB1,PGRN and NK cell subsets in SS patients were analyzed by Pearson correlation analysis.The risk factors of ILD in SS patients were analyzed by multivariate Logistic regression analysis.Results:Serum HMGB1 and PGRN were negatively correlated with CD3-CD16+CD56+NK count in SS patients(P＜0.001).The levels of HMGB1 and PGRN in ILD group were higher than those in non-ILD group,and the CD3-CD16+CD56+NK count was lower than that in non-ILD group(P＜0.05).Multivariate Logistic analysis showed that,advanced age,high HMGB1,and high PGRN were risk factors for ILD in SS patients,and elevated CD3-CD16+CD56+NK was a protective factor(all P＜0.05).Conclusion:Serum HMGB1 and PGRN are increased in SS patients,which are negatively correlated with NK cell subsets.Elevated serum HMGB1,PGRN and decreased NK cell subsets are the influencing factors of ILD in SS patients.
Sjogren's syndromeInterstitial lung diseaseHigh mobility group protein 1ProgranulinNK cell subsets
NETL
NSTL
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