The Efficacy and Safety Analysis of Beprost Sodium Combined with Sacubactril Valsartan Sodium Tablets in the Treatment of Essential Hypertension with Early Renal Insufficiency
Objective:To investigate the effect and safety of beproprost sodium combined with acubactrosovalsartan sodium tablets.Methods:106 patients with essential hypertension and early renal dysfunction diagnosed in our hospital from June 2022 to December 2023 were divided into control group and observation group,and 53 patients were selected in each group.Matched group:beproprost sodium,observation group:Shakubatrivalsartan sodium tablets+beproprost sodium.Compare the two groups of related indicators.Results:Compared with the matched group,the observation group had a high efficacy(P＜0.05).After treatment,both groups decreased CCr,CysC,β2-MG,MAU levels,eGFR,24 h diastolic/SBP,nocturnal diastolic/SBP,and the magnitude of change in the observed group was different compared with the control group(P＜0.05).The incidence of adverse reactions in the observed group was not different from the matched group(P＞0.05).Conclusion:The combination of beproprost sodium with sulbactrosovalsartan sodium tablets may improve the efficacy and safety.
Beprost sodiumPrimary hypertension with early renal insufficiencySacubactril valsartan sodium tablets
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