Value of Diffusion-Weighted Imaging Parameters Combined with Serum LncRNA-NEAT1 and miR-182-5p in the Evaluation of Preoperative Grading of Brain Glioma
Objective:To investigate the value of diffusion-weighted imaging(DWI)parameters combined with serum long-chain non-coding ribonucleic acids-nuclear enrichment rich transcript 1(LncRNA-NEAT1)and microRNA(miR)-182-5p in the evaluation of preoperative grading of brain glioma.Methods:112 brain glioma patients were divided into low-level group(60 cases)and high-level group(52 cases)according to postoperative pathological grading.All patients underwent DWI examination before operation to obtain apparent diffusion coefficient(ADC)and relative ADC(rADC)parameters.The expression of serum LncRNA-NEAT1 and miR-182-5p in brain glioma patients was detected.The value of DWI parameters combined with serum LncRNA-NEAT1 and miR-182-5p in the diagnosis of preoperative grading of brain glioma was analyzed by receiver operating characteristic(ROC)curve.Results:The ADC and rADC values in high-level group were lower than those in low-level group(P＜0.05),and the serum LncRNA-NEAT1 and miR-182-5p were higher than those in low-level group(P＜0.05).The area under the curve(AUC)of ADC,rADC,LncRNA-NEAT1 and miR-182-5p in the diagnosis of preoperative high-grade brain glioma was 0.834(95％CI:0.756～0.896),0.840(95％CI:0.762～0.900),0.784(95％CI:0.700～0.853),and 0.812(95％CI:0.731～0.878)respectively.AUC of combined diagnosis was 0.959(95％CI:0.907～0.987),which was higher than that of single index diagnosis.Conclusion:The ADC and rADC of patients with high-grade brain glioma decrease,and the serum LncRNA-NEAT1 and miR-182-5p increase,the combination of DWI parameters(ADC,rADC)and serum LncRNA-NEAT1 and miR-182-5p detection has high diagnostic value for preoperative grading of brain glioma.
NETL
NSTL
万方数据
