Expression and Clinical Significance of lncRNA VIM-AS1 and lncRNA LINC-PINT in Peripheral Blood Mononuclear Cells of Patients with Type 2 Diabetes
Objective:To investigate the expression and clinical significance of long non-coding RNA(lncRNA)VIM antisense RNA1(VIM-AS1)and lncRNA-p53 induced transcript(LINC-PINT)in peripheral blood mononuclear cells(PBMC)of patients with type 2 diabetes(T2DM).Methods:120 patients with T2DM(T2DM group),and 80 volunteers(NC group)were selected during the same period.The expression of lncRNA VIM-AS1,lncRNA LINC-PINT,glucose and lipid metabolism and insulin resistance were detected and compared between two groups.The value of lncRNA VIM-AS1,lncRNA LINC-PINT alone and in combination in predicting the occurrence of T2DM were analyzed by receiver operating characteristic(ROC)curve.Results:The expression of lncRNA VIM-AS1 and lncRNA LINC-PINT in T2DM group was lower than that in NC group(P＜0.05).The levels of triglyceride(TG),total cholesterol(TC),low density lipoprotein cholesterol(LDL-C),fasting plasma glucose(FPG),2 h postprandial blood glucose(2hPG),glycosylated hemoglobin(HbA1c),fasting insulin(FINS)and insulin resistance index(HOMA-IR)in T2DM group were higher than those in NC group,the level of high density lipoprotein cholesterol(HDL-C)was lower than that in NC group(P＜0.05).ROC curve showed that,the area under the curve(AUC)of lncRNA VIM-AS1 and lncRNA LINC-PINT alone and in combination to predict the occurrence of T2DM were 0.824,0.746 and 0.900,respectively,the combined predictive value was higher than that of each index alone.Conclusion:The low expression of lncRNA VIM-AS1 and lncRNA LINC-PINT in PBMC of patients with T2DM.The combined detection has a high predictive value for the occurrence of T2DM.
Type 2 diabetesPeripheral blood mononuclear cellslncRNA VIM-AS1lncRNA LINC-PINTPredictive value
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