Value of Systemic Immune Inflammatory Index Combined with Serum SCCA and VEGF-C in Evaluating the Risk of Postoperative Recurrence in Patients with HPV-Positive Cervical Cancer Undergoing Radical Resection
Objective:To investigate the value of systemic immune inflammation index(SII)combined with serum squamous cell carcinoma antigen(SCCA)and vascular endothelial growth factor-C(VEGF-C)in evaluating the risk of postoperative recurrence in patients with human papillomavirus(HPV)-positive cervical cancer undergoing radical resection.Methods:A total of 160 patients with HPV-positive cervical cancer in Maternal and Child Health Hospital of Hubei Province,Tongji Medical College,Huazhong University of Science and Technology from January 2019 to October 2021 were selected as the study subjects.According to the 2-year follow-up after operation,the recurrence was counted,and patients were divided into recurrence group and non-recurrence group,the clinicopathological data and levels of SII,SCCA and VEGF-C were compared between two groups.The influencing factors of postoperative recurrence in patients with HPV-positive cervical cancer were analyzed by multivariate Logistic regression.Results:SII,SCCA,VEGF-C in recurrence group were significantly higher than those in non-recurrence group(P＜0.05).FIGO stage,lymph node metastasis,SII,SCCA,VEGF-C were the influencing factors of postoperative recurrence in patients with HPV-positive cervical cancer(P＜0.05).Conclusions:SII,SCCA,and VEGF-C are significantly elevated in HPV positive cervical cancer patients with recurrence after radical surgery,and are independent factors for postoperative recurrence in HPV positive cervical cancer patients,joint testing helps evaluate the risk of recurrence in patients.
Human papilloma virusCervical carcinomaSIISCCAVEGF-CRecurrence
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