Relationship between the Expression of miR-338-3p and RAB23 in Thyroid Cancer Tissues and Clinicopathological Features and Prognosis
Objective:To investigate the relationship between the expression of microribonucleic acid-338-3p(miR-338-3p)and Ras oncogene family member 23(RAB23)in thyroid cancer(TC)tissues and clinicopathological features and prognosis.Methods:The intraoperatively resected TC tissues and adjacent tissues from 217 TC patients were collected.The expressions of miR-338-3p and the expressions of RAB23 mRNA in TC tissues and adjacent tissues were detected.The relationship between the expression of miR-338-3p and the expressions of RAB23 mRNA and the clinicopathological features of TC was analyzed.Kaplan-Meier method was used to analyze the survival of TC patients with high/low miR-338-3p and RAB23 mRNA expression.The influencing factors of poor prognosis in TC patients were analyzed by multivariate Cox regression.Results:Compared with adjacent tissues,the expression of miR-338-3p in TC tissues was decreased,and the expression of RAB23 mRNA was increased(P＜0.05).The expression of miR-338-3p and RAB23 mRNA was related to pathological type,TNM stage and lymph node metastasis(P＜0.05).After 3 years of follow-up,the 3-year overall survival rate of 217 TC patients was 83.41％(181/217).The 3-year overall survival rate in miR-338-3p high expression group was higher than that in miR-338-3p low expression group,and the 3-year overall survival rate in RAB23 mRNA high expression group was lower than that in RAB23 mRNA low expression group(P＜0.05).Multivariate Cox regression analysis showed that,miR-338-3p＜0.62,RAB23 mRNA≥ 2.13,lymph node metastasis,TNM stage Ⅲ～Ⅳ and low-thyroid/undifferentiated carcinoma were independent risk factors for poor prognosis in TC patients.Conclusion:The low expression of miR-338-3p and the high expression of RAB23 mRNA in TC tissues are risk factors for poor prognosis of TC patients,TNM stage and lymph node metastasis of TC patients.
Thyroid cancerMicroribonucleic acid-338-3pRas oncogene family member 23Pathological featuresPrognosis
NETL
NSTL
万方数据
