类风湿关节炎患者血清骨硬化蛋白、盐诱导激酶2与骨质疏松症的关系
Relationship between Serum Sclerostin,Salt-Induced Kinase 2 and Osteoporosis in Rheumatoid Arthritis Patients
薛艳艳 1邵平 1刘惠杰 1孙占娟 1相婷1
作者信息
- 1. 南京医科大学康达学院第一附属医院风湿免疫科 江苏连云港 222002
- 折叠
摘要
目的:研究探讨类风湿关节炎患者血清骨硬化蛋白(SOST)、盐诱导激酶2(SIK2)与骨质疏松症的关系.方法:选取2020年9月～2023年9月本院收治的180例类风湿关节炎患者为对象,根据患者骨质疏松症发生情况将其分为骨质疏松组和非骨质疏松组,比较两组患者血清SOST、SIK2水平及其他临床资料,并采用Logistic多因素回归分析类风湿关节炎患者发生骨质疏松症的影响因素.结果:骨质疏松组年龄、类风湿关节炎病程、女性比例、使用糖皮质激素比例大于非骨质疏松组,血清SOST、SIK2均高于非骨质疏松组(P＜0.05).经Logistic多因素回归分析显示,高龄、类风湿关节炎病程长、SOST、SIK2升高是类风湿关节炎发生骨质疏松症的危险因素(P＜0.05).结论:血清SOST、SIK2在类风湿关节炎合并骨质疏松症患者中升高,且血清SOST、SIK2升高是类风湿关节炎患者发生骨质疏松症的危险因素.
Abstract
Objective:To investigate the relationship between serum sclerostin(SOST),salt-induced kinase 2(SIK2)and osteoporosis in rheumatoid arthritis patients.Methods:A total of 180 rheumatoid arthritis patients admitted to our hospital from September 2020 to September 2023 were selected and divided into osteoporosis group and non-osteoporosis group according to the occurrence of osteoporosis.Serum SOST,SIK 2 levels and other clinical data were compared between the two groups,and Logistic multivariate regression was used to analyze the influencing factors of osteoporosis in patients with rheumatoid arthritis.Results:Age,rheumatoid arthritis duration,female proportion and glucocorticoid use in the osteoporosis group were greater than the non-osteoporosis group,and Serum SOST and SIK 2 were higher than the non-osteoporosis group(P＜0.05).The advanced age,long duration of rheumatoid arthritis,elevated SOST and elevated SIK 2 were risk factors for rheumatoid arthritis with osteoporosis by Logistic multiple regression analysis(P＜0.05).Conclusion:Serum SOST and SIK 2 were elevated in patients with rheumatoid arthritis complicated with osteoporosis,and elevated serum SOST and SIK 2 are the risk factors for osteoporosis in patients with rheumatoid arthritis.
关键词
类风湿关节炎/骨质疏松症/骨硬化蛋白/盐诱导激酶2Key words
Rheumatoid arthritis/Osteoporosis/Sclerostin/Salt-induced kinase 2引用本文复制引用
出版年
2024
NETL
NSTL
万方数据