Relationship between Serum Sclerostin,Salt-Induced Kinase 2 and Osteoporosis in Rheumatoid Arthritis Patients
Objective:To investigate the relationship between serum sclerostin(SOST),salt-induced kinase 2(SIK2)and osteoporosis in rheumatoid arthritis patients.Methods:A total of 180 rheumatoid arthritis patients admitted to our hospital from September 2020 to September 2023 were selected and divided into osteoporosis group and non-osteoporosis group according to the occurrence of osteoporosis.Serum SOST,SIK 2 levels and other clinical data were compared between the two groups,and Logistic multivariate regression was used to analyze the influencing factors of osteoporosis in patients with rheumatoid arthritis.Results:Age,rheumatoid arthritis duration,female proportion and glucocorticoid use in the osteoporosis group were greater than the non-osteoporosis group,and Serum SOST and SIK 2 were higher than the non-osteoporosis group(P＜0.05).The advanced age,long duration of rheumatoid arthritis,elevated SOST and elevated SIK 2 were risk factors for rheumatoid arthritis with osteoporosis by Logistic multiple regression analysis(P＜0.05).Conclusion:Serum SOST and SIK 2 were elevated in patients with rheumatoid arthritis complicated with osteoporosis,and elevated serum SOST and SIK 2 are the risk factors for osteoporosis in patients with rheumatoid arthritis.
NETL
NSTL
万方数据
