Changes in Serum ps-Tg,MMP-13,and TgAb Levels before and after Surgery in Patients with Differentiated Thyroid Cancer and Their Correlation with Postoperative Recurrence and Metastasis
Objective:To explore the changes of serum ps-Tg,MMP-13,and TgAb in patients with differentiated thyroid carcinoma before and after surgery,and their correlation with postoperative recurrence and metastasis.Methods:100 differentiated thyroid cancer patients admitted from 2018.1 to 2021.1 in our hospital were treated with radical surgery for 3-year follow-up to record the changes in serum level.The incidence of postoperative recurrence and metastasis was recorded and divided into recurrence group(n=25)and non-recurrence group(n=75).Comparing serum levels,Spearman correlation analysis and predicted value was used for logistic regression analysis.Result:The levels of ps-Tg,MMP-13 and TgAb were lower than before surgery(P＜0.05),However,there was no difference in 1 year compared with 3 years after surgery(P＞0.05);The expression level and percentage decrease of serum ps-Tg,MMP-13 and Tg Ab between 1-year patients of recurrence and non-recurrence patients,The group with recurrent metastasis was higher than the non-recurrent metastasis group(P＜0.05);Spearman Correlation analysis showed that ps-Tg,MMP-13 and TgAb were positively correlated with the recurrence and metastasis of differentiated thyroid carcinoma after surgery(P＜0.05);logistics From the regression model analysis,The ps-Tg,MMP-13 and TgAb were all classified as independent influencing factors(P＜0.05).Conclusion:The serum levels of ps-Tg,MMP-13,and TgAb gradually decrease in patients with differentiated thyroid cancer after surgery for 1 year,and show a stable state from 1 to 3 years after surgery.The serum levels of ps-Tg,MMP-13,and TgAb are closely related to the postoperative recurrence and metastasis.
ps-TgMMP-13TgAbDifferentiated thyroid cancerRadical surgery
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