Peripheral Blood TLR2,CD64 and STREM-1 Levels in Childten with Infectious Diarrhea and Their Value in Differential Diagnosis
Objective:To investigate peripheral blood Toll-like receptor 2(TLR2),cluster of differentiation antigen 64(CD64)and soluble triggering receptor expressed on myeloid cell-1(STREM-1)in children with infectious diarrhea,and their value in differential diagnosis of infectious diarrhea.Methods:A total of 64 children with infectious diarrhea admitted to the hospital from April 2020 to July 2023 were selected,and divided into bacterial diarrhea group(n=33)and viral diarrhea group(n=31)according to the type of pathogen.Meanwhile,30 healthy children were selected as the control group.Peripheral blood TLR2,CD64,and STREM-1 levels in all groups were measured.The diagnostic value of the three indicators in children with infectious diarrhea was analyzed using the receiver operating characteristic(ROC)curves.Results:TLR2 levels in the bacterial diarrhea group and the viral diarrhea group were higher than those in the control group.CD64 and STREM-1 levels in the bacterial diarrhea group were higher than those in the viral diarrhea group and the control group(P＜0.05).ROC curve analysis results showed that the area under the curve(AUC)of STREM-1 was the largest,which was 0.777.Its sensitivity and specificity were 62.50％and 93.33％.The AUC of joint diagnosis was 0.839.The sensitivity and specificity were 84.37％and 83.33％.Conclusion:For diagnosing children with infectious diarrhea using peripheral blood TLR2,CD64,and STREM-1,the diagnostic efficacy of STREM-1 is the highest.Combination of the three can significantly improve the diagnostic sensitivity.
Infectious diarrheaToll-like receptor 2Cluster of differentiation antigen 64Soluble triggering receptor expressed on myeloid cell-1
NETL
NSTL
万方数据
