Differential Diagnosis and Prognostic Value Analysis of Serum Soluble CD276,Growth Differentiation Factor 15 Combined with Thymidine Kinase in High-grade and Low-grade Serous Ovarian Cancer
Objective:To investigate the differential diagnosis and prognostic value of serum sCD276,CDF15 and TK1 in high and low grade serous ovarian cancer.Methods:60 patients with serous ovarian cancer admitted to our hospital from January 2019 to January 2019 were divided into high-grade group(n=32)and low-grade group(n=28),and 30 patients with benign ovarian tumor admitted during the same period were selected as control group.The patients were followed up for 3 years and divided into poor prognosis group(n=20)and good prognosis group(n=40).The correlation indexes of the two groups were compared and the prognostic value was discussed.Results:sCD276,CDF15 and TK1 in high-grade group were higher than those in other two groups(P＜0.05);ROC curve showed that the sensitivity and specificity of combined diagnosis were higher than that of single diagnosis.In prognosis analysis,FIGO stage,lymph node metastasis,distant metastasis,tumor differentiation,sCD276,CDF15 and TK1 expression levels were different between the two groups(P＜0.05).logistic regression analysis showed that FIGO stage,distant metastasis,sCD276,CDF15 and TK1 were independent prognostic factors of high and low grade serous ovarian cancer(P＜0.05).Conclusion:sCD276,CDF15 and TK1 are of great significance in the identification of high and low grade serous ovarian cancer,and the combined diagnosis of SCD276,CDF15 and TK1 has high sensitivity and specificity,which can further predict the prognosis of serous ovarian cancer.
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