Effect of Citicoline Combined with Oxiracetam on Cognitive Function,Neurotransmitter Level and Inflammatory Stress Response in Elderly Patients with Cognitive Dysfunction after Hypertensive Cerebral Hemorrhage
Objective:To investigate the changes of neurotransmitters,cognitive function and inflammatory stress response in elderly patients with cognitive dysfunction after hypertensive cerebral hemorrhage(HICH)treated with citicoline combined with oxiracetam.Methods:According to the random number table method,92 elderly patients with cognitive dysfunction after HICH were divided into control group(oxiracetam treatment,46 cases)and observation group(citicoline combined with oxiracetam treatment,46 cases).The total clinical effective rate,cognitive function,neurotransmitter level,inflammatory stress response index were observed between two groups after treatment.Results:The total clinical effective rate in observation group was higher than control group(P＜0.05).Compared with control group,the scores of montreal cognitive assessment(MoCA),mini-mental state examination(MMSE)and the levels of serum glycine(Gly),γ-aminobutyric acid(GABA),superoxide dismutase(SOD)and glutathione peroxidase(GSH-Px)were increased,and the levels of glutamic acid(Glu),aspartic acid(Asp),tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),high mobility group protein B1(HMGB1)and malondialdehyde(MDA)were decreased in observation group 2 weeks after treatment(P＜0.05).Conclusion:Citicoline combined with oxiracetam in the treatment of elderly patients with cognitive dysfunction after HICH,can effectively improve the cognitive function of patients,which may be related to regulating neurotransmitter levels and reducing inflammatory stress response.
NETL
NSTL
万方数据
