Effects of Jinlida Granules Combined with Semeglutide on Glycolipid Metabolism,Inflammatory Markers and Arteriosclerosis Indexes in Patients with Type 2 Diabetes Mellitus Combined with Carotid Atherosclerosis
Objective:To observe the changes of inflammatory markers,glucose and lipid metabolism,and atherosclerosis indicators in patients with type 2 diabetes mellitus(T2DM)and carotid atherosclerosis(CAS)treated with smeglutide and Jinlida granules.Methods:138 patients with T2DM combine with CAS were divided into control group and observation group according to the random number table method,the number of cases in both groups was 69.All patients received basic treatment,control group received semeglutide treatment,and observation group received jinlida granules combine with semeglutide treatment.The total clinical effective rate,glycolipid metabolism indexes,inflammatory markers and arteriosclerosis indexes were compared in two groups.Results:The total clinical effective rate in observation group was higher than that in control group(P＜0.05).Compared with control group,the level of high density lipoprotein cholesterol(HDL-C)in observation group was higher after treatment,fasting plasma glucose(FPG),glycosylated hemoglobin(HbA1c),total cholesterol(TC),2-hour postprandial blood glucose(2hPG),low-density lipoprotein cholesterol(LDL-C),triglyceride(TG)levels and neutrophil-lymphocyte ratio(NLR),lymphocyte-monocyte ratio(LMR),platelet-lymphocyte ratio(PLR),carotid intima-media thickness(CIMT),resistance index(RI),carotid-femoral pulse wave velocity(cfPWV),arterial reflection wave enhancement index(Alx)were lower(P＜0.05).Conclusion:Jinlida granules combined with semeglutide in the treatment of patients with T2DM combined with CAS can further improve the clinical efficacy,which is closely relate to the improvement of glycolipid metabolism,inflammatory markers and arteriosclerosis indexes.
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