The Predictive Value of Immune Thrombus for Cerebral Infarction and Its Relationship with Short-term Recurrence after Thrombolytic Therapy
Objective:To analyze the predictive value of immune thrombus and carbohydrate antigen in cerebral infarction and its relationship with short-term recurrence after thrombolysis.Methods:105 patients with cerebral infarction admitted to our hospital from January 2019 to January 2019 were selected as the observation group.Another 105 healthy subjects in the same period were selected as control group.Relevant indexes of all participants were detected,and the relationship between immune thrombus and carbohydrate antigen with NIHSS score and infarct diameter in cerebral infarction patients was analyzed.ROC was used to evaluate the efficacy of immune thrombus and carbohydrate antigen in diagnosing cerebral infarction and predicting short-term recurrence after thrombolysis.Results:The levels of immune thrombus and CA125 in observation group were higher than those in control group(P＜0.05).The levels of immune thrombus and CA125 in patients with severe defect were higher than those in patients without severe defect(P＜0.05).The expression levels of TM,TAT,PIC and CA125 in peripheral blood of patients with cerebral infarction were positively correlated with NIHSS score and infarction diameter by Pearson correlation analysis(P＜0.05).ROC curve analysis showed that the specificity,sensitivity and AUC of TM,TAT and PIC combined with CA125 in the diagnosis of cerebral infarction were 90.67％,54.37％and 0.925.The specificity,sensitivity and AUC of short-term recurrence after thrombolysis were 91.27％,53.68％and 0.917.Conclusion:The expression of TM,TAT,PIC and CA125 in peripheral blood of patients with cerebral infarction is significantly up-regulated,and is closely related to the severity of the disease.Combined application can improve the efficacy of diagnosing cerebral infarction and predicting short-term recurrence after thrombolysis.
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