The Effect of Intravenous Immunoglobulin Combined with Aspirin on Lymphocyte Subsets and Related Factor Levels in Children with Kawasaki Disease
Objective:To explore the effect of intravenous immunoglobulin combined with aspirin drugs on the levels of lymphocyte subsets and related factors in children with Kawasaki disease.Methods:105 children with Kawasaki disease admitted from March 2023 to February 2024 were selected and divided into 45 children in the control group with aspirin alone,and 60 children in the observation group were treated with intravenous immunoglobulin combined with aspirin.Compare the two groups of related indicators.Results:The total response rate was significantly higher than the observation group(P＜0.05);the values of CD4+,CD3+,CD4+and CD4+/CD8+increased in the observation group(P＜0.05);IFN-γ,TNF-α,IL-2,IL-4,were lower than the observation group(P＜0.05);the incidence of adverse reactions between the two groups(P＞0.05).Conclusion:Intravenous immunoglobulin combined with aspirin in the treatment of Kawasaki disease has a remarkable effect,which can improve the level of lymphocyte subsets and related factors,then improve immune function,reduce inflammatory response,and have high safety.
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