Study on the Relationship between the FOXP1 and FOXR2 Expression in Breast Invasive Lobular Carcinoma Tissues and Clinicopathological Features and Prognosis
Objective:To investigate the relationship between the forkhead box protein P1(FOXP1)and FOXR2 expression in breast invasive lobular carcinoma(ILC)tissues and clinicopathological features and prognosis.Methods:248 breast ILC patients were selected,and the relationship between FOXP1 and FOXR2 expression in breast ILC tissues and clinicopathological features were analyzed.According to the FOXP1 and FOXR2 expression in breast ILC tissues,breast ILC patients were divided into positive/negative expression groups,survival curves of each group were drawn using the Kaplan-Meier method,the factors affecting the prognosis of breast ILC patients was analyzed by multivariate Cox regression analysis.Results:Compared with adjacent tissues,the FOXP1 positive expression rate in breast ILC tissues was decreased,and the FOXR2 positive expression rate was increased(P＜0.05).The FOXP1 and FOXR2 expression in breast ILC tissues were related to the differentiation degree,TNM stage and lymph node metastasis(P＜0.05).3 years after follow-up,the overall survival rate of 248 breast ILC patients was 69.11％.The overall survival rate in FOXP1 positive expression group was higher than that in negative expression group,and the overall survival rate in FOXR2 positive expression group was lower than that in negative expression group(P＜0.05).The independent risk factors for death in breast ILC patients included TNM stage Ⅲ～Ⅳ,triple negative and FOXR2 positive,and the independent protective factor was FOXP1 positive(P＜0.05).Conclusions:The FOXP1 positive expression in breast ILC tissues is decreased,and the FOXR2 positive expression is increased,its abnormal expression is related to the differentiation degree,TNM stage and other malignant pathological features and poor prognosis.
Breast invasive lobular carcinomaForkhead box protein P1Forkhead box protein R2Clinicopathological featuresPrognosis
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