Evaluation Value of Prognosis of Neutrophil CD64 Index Combined with Serum APOM and HMGB1 in Patients with Sepsis Caused by Bacterial Bloodstream Infection
Objective:To study the evaluation value of prognosis of neutrophil CD64 index combined with serum apolipoprotein M(APOM)and high mobility group protein B1(HMGB1)in patients with sepsis caused by bacterial bloodstream infection.Methods:251 patients with sepsis caused by bacterial bloodstream infection were divided into survival group and death group according to whether they experienced mortality after 28 days of admission.The influencing factors of 28 d mortality were analyzed by Logistic regression model,the value of CD64 index,serum APOM,HMGB1 and conventional infection indicators in predicting 28 d mortality in patients with sepsis caused by bacterial bloodstream infection were analyzed by receiver operating characteristic(ROC)curve.Results:Compared with survival group,the neutrophil CD64 index and HMGB1 in death group were significantly increased,and the serum APOM was significantly decreased(P＜0.05).High APACHEII score,high procalcitonin,high neutrophil CD64 index,high C-reactive protein,high HMGB1,and low APOM were risk factors for 28 d mortality in patients with sepsis caused by bacterial bloodstream infection(P＜0.05).ROC curve showed that,the area under the curve(AUC)of procalcitonin,C-reactive protein,neutrophil CD64 index,APOM and HMGB1 in predicting the 28 d mortality risk of sepsis patients caused by bacterial bloodstream infection was 0.917,which was greater than that predicted by single index.Conclusion:The increase of neutrophil CD64 index,HMGB1 and the decrease of APOM are related to the risk of 28 d mortality in patients with sepsis caused by bacterial bloodstream infection,and combined with procalcitonin and C-reactive protein has a high predictive value.
Neutrophil CD64 indexApolipoprotein MHigh mobility group protein B1Bacterial bloodstream infectionSepsisPrognosis
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