Clinical Value of Detection of CMTM3 and CMTM6 in Gastric Adenocarcinoma
Objective:To evaluate the clinical value of detection of chemotin-like factor superfamily(CMTM)3 and CMTM6 in gastric adenocarcinoma.Methods:155 gastric adenocarcinoma patients who underwent surgical treatment in our hospital were selected,,and the expression of CMTM3 and CMTM6 in the cancerous and adjacent tissues during surgery was detected.Followed up for 3 years.The relationship between the expression of CMTM3 and CMTM6 and the clinicopathological features and the 3-year overall survival(OS)of gastric adenocarcinoma patients was analyzed.The factors affecting the prognosis of gastric adenocarcinoma patients were analyzed by multivariate COX regression analysis.Results:Compared with adjacent tissues,the positive expression rate of CMTM3 was lower and the positive expression rate of CMTM6 was higher in cancer tissues(P＜0.05),and the positive expression rate of CMTM6 was higher than that in adjacent tissues(P＜0.05).The positive expression of CMTM3 and CMTM6 was related to the degree of differentiation,TNM stage and lymph node metastasis of gastric adenocarcinoma(P＜0.05).The 3-year OS rate of CMTM3,CMTM6 positive expression gastric adenocarcinoma patients was lower than that of CMTM3,CMTM6 negative expression gastric adenocarcinoma patients(P＜0.05).The risk factors for poor prognosis in gastric adenocarcinoma patients include TNM stage Ⅲ,positive expression of CMTM6,and lymph node metastasis(P＜0.05),while the protective factor is positive expression of CMTM3(P＜0.05).Conclusion:The positive expression rate of CMTM3 in gastric adenocarcinoma tissues is decrease,and the positive expression rate of CMTM6 is increase,which are relate to poor differentiation,TNM stage Ⅲ,lymph node metastasis and low OS of gastric adenocarcinoma.
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