FS-LASIK围术期应用0.05％环孢素滴眼液(Ⅱ)对术后干眼症状及泪膜稳定性的影响
Effect of 0.05％Cyclosporine Eye Drops(Ⅱ)on Dry Eye Symptoms and Tear Film Stability after FS-LASIK
黄鸿艳 1王新雨 1包春凤 2黄丽雪 3王大庆 1沈志斌3
作者信息
- 1. 川北医学院眼视光医学院 四川南充 637100
- 2. 成都中医药大学眼科学院 四川成都 611130
- 3. 达州市中心医院眼科 四川达州 635000
- 折叠
摘要
目的:观察飞秒激光辅助准分子激光原位角膜磨镶术(FS-LASIK)围术期应用0.05％环孢素(CsA)滴眼液(Ⅱ)对术后干眼症状及泪膜稳定性的影响.方法:92例行FS-LASIK手术且术后出现干眼症状的患者分为术前使用0.05％CsA滴眼液(Ⅱ)组(A组)36例、术后1周开始使用0.05％CsA滴眼液(Ⅱ)组(B组)32例、不使用0.05％CsA滴眼液(Ⅱ)组(C组)24例.对比三组中国干眼问卷评分、泪膜破裂时间(BUT)、角膜荧光素染色(FL)、结膜丽丝胺绿染色(LG)、泪液分泌试验(SIt).结果:B组、C组术后1周、1个月及3个月中国干眼问卷评分、FL、LG高于A组,且C组高于B组(P＜0.05).B组、C组术后1周、1个月及3个月BUT、SIt低于A组,且C组低于B组(P＜0.05).结论:FS-LASIK术前使用0.05％CsA滴眼液(Ⅱ)可以有效缓解患者术后干眼症状,提高泪膜稳定性.
Abstract
Objective:To observe the effect of perioperative application of 0.05％cyclosporine(CsA)eye drops(Ⅱ)on dry eye symptoms and tear film stability after femtosecond laser-assisted laser in situ keratomileusis(FS-LASIK).Methods:92 patients who underwent FS-LASIK surgery and had dry eye symptoms after surgery were divided into 36 patients who used 0.05％CsA eye drops before operation(group A),32 patients who used 0.05％CsA eye drops 1 week after operation(group B),and 24 patients who did not use 0.05％CsA eye drops(group C).The Chinese dry eye questionnaire score,tear film rupture time(BUT),corneal fluorescein staining(FL),conjunctival lissamine green staining(LG),and tear secretion test(SIt)were compared among three groups.Results:The Chinese dry eye questionnaire score,FL and LG in group B and group C were higher than those in group A at 1 week,1 month and 3 months after operation,and those in group C were higher than those in group B(P＜0.05).BUT and Sit in group B and group C were lower than those in group A at 1 week,1 month and 3 months after operation,and those in group C were lower than those in group B(P＜0.05).Conclusion:The use of 0.05％CsA eye drops(Ⅱ)before FS-LASIK can effectively alleviate the symptoms of dry eye,and improve the stability of tear film.
关键词
飞秒激光辅助准分子激光原位角膜磨镶术/环孢素滴眼液/干眼症状/泪膜稳定性Key words
Femtosecond laser-assisted laser in situ keratomileusisis/Cyclosporine eye drops/Dry eye symptoms/Tear film stability引用本文复制引用
出版年
2024
NETL
NSTL
万方数据