摘要
目的:探讨不同性别高尿酸血症患者中血清尿酸(SUA)、甲状腺激素水平及炎症水平差异,分析其与高尿酸血症疾病严重程度的相关性分析.方法:选取我院2021年1月到2023年12月收治的100例高尿酸血症患者,依照其性别进行分组,分为男性组(n=57)与女性组(n=43).对比两组患者相关指标.将100例高尿酸血症患者依照症状严重程度分为轻度组(n=33)、中度组(n=45)及重度组(n=22),对比三组患者相关指标并分析血清SUA、甲状腺激素水平及炎症水平与高尿酸血症疾病严重程度的相关性.结果:男性组痛风性关节炎、痛风石形成发生率高于女性组,女性组无症状性高尿酸血症发生率高于男性组(P＜0.05);男性组IL-6、TNF-α及hs-CRP表达水平高于女性组(P＜0.05);不同病情严重程度患者SUA、甲状腺激素水平及炎症水平对比差异显著,重度组SUA、TSH、IL-6、TNF-α、hs-CRP水平高于轻度组与中度组,重度组FT3、FT4水平低于轻度组与中度组(P＜0.05);Spearman相关分析结果显示:SUA、TSH、IL-6、TNF-α、hs-CRP与高尿酸血症病情严重程度呈正相关,FT3、FT4与高尿酸血症病情严重程度呈负相关(P＜0.05).结论:不同性别高尿酸血症患者临床表现具有显著差异,炎症因子水平具有差异,血清SUA、甲状腺激素水平及炎症水平与高尿酸血症疾病严重程度具有密切关系.
Abstract
Objective:Study differences in serum uric acid(SUA),thyroid hormones,and inflammatory markers between genders in hyperuricemia patients,and analyze their correlation with disease severity.Methods:100 hyperuricemia patients(2021-2023)were grouped by gender(male:57,female:43).Compared relevant indicators between groups.Patients were further stratified by severity(mild:33,moderate:45,severe:22)to analyze SUA,thyroid hormones,inflammation,and their correlation with severity.Results:Males had higher gouty arthritis and tophus rates,while females had more asymptomatic hyperuricemia(P＜0.05).Males had higher IL-6,TNF-α,and hs-CRP levels(P＜0.05).SUA,TSH,and inflammatory markers increased with severity,while FT3 and FT4 decreased(P＜0.05).Spearman analysis showed SUA,TSH,IL-6,TNF-α,hs-CRP positively correlated,and FT3,FT4 negatively correlated with severity(P＜0.05).Conclusion:Gender differences impact hyperuricemia manifestations and inflammation.SUA,thyroid hormones,and inflammation are closely related to disease severity.
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