Study on the Relationship between Serum 25-(OH)D3,sVCAM-1,MMP-9 and Intrahepatic Cholestasis of Pregnancy in Pregnant Women with Chronic Hepatitis B Virus Infection
Objective:To investigate the relationship between serum 25-hydroxyvitamin D3[25-(OH)D3],soluble vascular cell adhesion molecule-1(sVCAM-1),matrix metalloproteinase-9(MMP-9)and intrahepatic cholestasis of pregnancy(ICP)in pregnant women with chronic hepatitis B(CHB)virus infection.Methods:120 pregnant women with CHB virus infection with ICP admitted to the Maternal and Child Health Hospital of Hubei Province,Tongji Medical College,Huazhong University of Science and Technology from January 2021 to December 2023 were selected as the study subjects(combined group),and 100 pregnant women with CHB virus infection without ICP were selected as control(non-combined group),the levels of serum 25-(OH)D3,sVCAM-1 and MMP-9 were compared between two groups.The related factors of ICP were analyzed by univariate and multivariate Logistic regression analysis.Results:The levels of serum sVCAM-1 and MMP-9 in combined group were higher than those in non-combined group(P＜0.05),and 25-(OH)D3 was lower than that in non-combined group(P＜0.05).Multivariate Logistic regression analysis showed that,elevated serum sVCAM-1 and MMP-9 were risk factors for ICP in pregnant women with CHB virus infection,and elevated 25-(OH)D3 was a protective factor for ICP in pregnant women with CHB virus infection(all P＜0.05).Conclusion:Serum 25-(OH)D3,sVCAM-1 and MMP-9 in pregnant women with CHB virus infection are closely relate to the occurrence of ICP.
Chronic hepatitis B virus infectionIntrahepatic cholestasis of pregnancy25-(OH)D3sVCAM-1MMP-9
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