Effects of Shumian Capsules Combined with Agomelatine Tablets on Polysomnography Characteristics and Serum 5-HT,BDNF and GDNF in Patients with Depression and Insomnia
Objective:To investigate the effects of shumian capsules combined with agomelatine tablets on polysomnography characteristics and serum 5-hydroxytryptamine(5-HT),glial cell line-derived neurotrophic factor(GDNF)and brain-derived neurotrophic factor(BDNF)in patients with depression and insomnia.Methods:94 patients with depression and insomnia who were divided into study group(treated with agomelatine tablets and shumian capsules)and control group(treated with agomelatine tablets)according to the random number table method,47 cases in each group.The Hamilton Depression Scale-17(HAMD-17),Pittsburgh Sleep Quality Index(PSQI),Fatigue Scale(FS-14)scale score,5-HT,BDNF,GDNF,polysomnography(PSG)related indicators[total sleep time(TST),sleep efficiency(SE),non-rapid eye movement sleep 1,2,3(NREM1,NREM2,NREM3)]were compared between two groups.Results:Compared with control group after treatment,the scores of HAMD-17,PSQI and FS-14 in study group were relatively lower(P＜0.05).Compared with control group after treatment,5-HT,BDNF and GDNF in study group were relatively higher(P＜0.05).Compared with control group after treatment,TST,SE,NREM1,NREM2 and NREM3 in study group were relatively higher(P＜0.05).Conclusion:Patients with depression and insomnia are treat with agomelatine tablets and shumian capsules,the symptoms of insomnia and depression are significantly improve,which may be relate to the improvement of serum 5-HT,BDNF and GDNF levels.
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