Effect of Myocardial Infarction,Heart Failure and Atrial Fibrillation on Cerebrovascular Accidents:a Mendelian Randomized Study
Objective:Traditional studies have shown a close association between myocardial infarction(MI),heart failure(HF),atrial fibrillation(AF)and cerebrovascular accidents(CVA)among cardiovascular diseases from both observational and empirical per-spectives,but a causal relationship between the above cardiovascular diseases and CVA has not yet been confirmed.Therefore,we con-ducted a Mendelian randomization(MR)study to investigate the causal relationship between MI,HF,AF and CVA.Methods:MR esti-mation was performed using the inverse variance weighting method,weighted median method,and MR Egger method.Cochran's Q test,MR-Egger intercept test,MR-PRESSO,MR Steiger test,leave-one-out analysis,and funnel plot were used in sensitivity analysis.In addi-tion,exposure SNPs associated with myocardial infarction,AF,and AF were collated.Results:MI,HF,and AF were Mendelian random-ized to CVA separately,and MR-Egger results showed that MI was associated with the risk of CVA(MI vs.CVA,P＜0.05,OR(95％CI):420.722(3.45 to 51171.12));HF was associated with the risk of CVA(HF vs.CVA,OR(95％CI):1.324(1.14 to 1.53));AF was associ-ated with the risk of CVA(AF vs.CVA,P＜0.05,OR(95％CI):58671.12).Conclusion:This MR study provides preliminary evidence that the causal association of MI,HF and AF with CVA is reliable.
Cardiovascular diseaseCerebrovascular accidentMendelian randomization(MR)Myocardial infarctionHeart failureAtrial fibrillationGenome-wide association study(GWAS)
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