Analysis of the Differential Expression of OCT Parameters and Laboratory Serum Indicators and Prognostic Factors in Patients with Diabetic Macular Edema before and after Treatment with Ranibizumab
Objective:To investigate the differential expression of optical coherence tomography(OCT)parameters,laboratory serum indicators and prognostic factors in patients with diabetic macular edema(DME)before and after treatment with Ranibizumab.Methods:Retrospective analysis of 92 DME patients(130 eyes)admitted from April 2022 to November 2023,comparing various indica-tors of the patients.After 4 months of treatment,patients were divided into a good prognosis group of 70 cases(90 eyes)and a poor prog-nosis group of 22 cases(40 eyes)based on the thickness of the central retina in the macular area.The prognostic factors of DME patients treated with ranibizumab were analyzed.Results:After 4 months of treatment,the SND height and CST of the patient decreased(P＜0.05);After one month of treatment,the average levels of IL-8,VEGF,and IL-6 decreased,while PEDF increased(P＜0.05);There were signifi-cant differences(P＜0.05)in age,lesion grading,disease classification,SND height,CST,VEGF,and IL-6 expression levels among patients in the prognostic group;Disease grading,CST,VEGF,and IL-6 are independent prognostic risk factors for DME patients treated with ranibizumab(P＜0.05).Conclusion:Ranibizumab treatment of DME can improve its OCT parameters,reduce serum levels of IL-8,VEGF,IL-6,and increase the level of PEDF.However,observation of macular edema stage,CST,VEGF,and IL-6 levels before treat-ment can provide an important reference for predicting the prognosis of early patients.
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