Study on the Effect of Guilu Erxian Glue on Immune Cytokines and TGF-β1/Smad Signaling Pathway in Patients with Advanced Colorectal Cancer
Objective:To investigate the effect of Guilu Erxian Glue on immune cytokines and transforming growth factor-βi(TGF-β1)/Drosophila mothers against decapentaplegic protein(Smad)signaling pathway in patients with advanced colorectal cancer.Methods:82 patients with advanced colorectal cancer were divided into control group and observation group according to the two-color ball method,41 cases each.Control group received FOLFIRI regimen chemotherapy,and observation group received Guilu Erxian Glue and FOLFIRI regimen chemotherapy.The traditional Chinese medicine syndrome scores,immune cytokines and serum TGF-β1/Smad signaling pathway indexes in two groups before and after treatment were compared,and the incidence of adverse reactions in two groups was observed.Results:Compared with control group after treatment,the scores of traditional Chinese medicine syndromes(obvious fa-tigue,decreased appetite,soreness and weakness of waist and knees,shortness of breath,thin stool),CD8+and serum TGF-β1,Smad3 levels in observation group were lower,and serum Smad7 levels,CD4+,natural killer(NK)cells,CD4+/CD8+were higher(P＜0.05).There was no difference in the incidence of adverse reactions between control group(41.46％)and observation group(29.27％)(P＞0.05).Con-clusion:Guilu Erxian Glue may assist in improving the clinical symptoms of patients with advanced colorectal cancer by regulating immune cytokines and inhibiting TGF-β1/Smad signaling pathway.
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