Clinical Significance of Serum Late Glycation End Product Detection on Complications of Type 2 Diabetes Mellitus and its Association with Diet
Objective:To explore the effects of AGEs as risk factors and other clinical indicators on the progression of type 2 dia-betes complications at different stages,and the effects of risk factors such as dietary nutrient intake,dietary score and AGEs on the pro-gression of type 2 diabetes complications at different stages.Methods:A total of 318 patients from the Department of Endocrinology of Tangdu Hospital were enrolled and divided into simple group,combined group(microvascular disease group,macrovascular disease group,microvascular and macrovascular disease group),and healthy group(30 cases)according to the guidelines for the prevention and treatment of type 2 diabetes mellitus(2020 edition).After the homogeneity test of normal distribution and variance of AGEs and other clinical risk factors,parametric and non-parametric univariate analysis was performed according to the results,and multiple logistic regression was constructed to predict the risk model of type 2 diabetes mellitus progression to complications based on serum AGEs and risk factors,and multiple regression analysis between AGEs and risk factors.A Spearman rank correlation test and cluster analysis were constructed for nutrient content,dietary pattern scores,AGEs and comorbidity progression.Results:There were statistically significant differences in AGEs,age,SBP,course of disease,HCY,SCR,GFR,CysC,Ca,Apo-B,TC,TG,and LDL-C between the simple group and the combined group(P＜0.05).There were statistically significant differences in AGEs,heart rate,age,SBP,course of disease,HCY,SCR,GFR,CysC,Apo-B,TC,HDL-C,and LDL-C among the simple group,microvascular group,macrovascular group,and microvas-cular and macrovascular groups(P＜0.05).Multivariate Logistic regression analysis showed that increasing age,increased heart rate,pro-longed disease course,and elevated CysC were independent risk factors for type 2 diabetes comorbidities,while elevated AGEs and ele-vated Ca were independent protective factors.Multiple linear regression analysis showed that BMI,Ca,ALT and DBP had negative ef-fects on AGEs,while GFR,AST,TC and disease course had positive effects on AGEs(P＜0.05).Correlation analysis showed that AGEs were closely related to HEI-total score,AHEI-total score,and DBI-2022 low bound score.Cluster analysis showed that AGEs were close to HEI and AHEI.Conclusion:AGEs and a variety of clinical factors play a certain role in the progression of type 2 diabetes mellitus and complications,and the combination of multiple dietary pattern scores with AGEs can assess the risk of progression to type 2 diabetes and its comorbidities in healthy people,and give more specific guidance and improvement at the dietary level.
Type 2 diabetesType 2 diabetes complicationsAdvanced glycation end products(AGEs)Semi-Quantitative Food Fre-quency Questionnaire(SQFFQ)
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