SII联合MHR对ICAS相关缺血性卒中急性期进展的预测价值

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中文摘要：目的:探讨全身免疫炎症指数(Sn)联合单核细胞高密度脂蛋白比值(MHR)对ICAS相关缺血性卒中急性期发生进展的预测价值。方法:回顾性收集2021年1月-2023年7月于徐州医科大学附属医院住院的ICAS相关缺血性卒中患者280例，根据发病7天内NIHSS评分是否较基线增加≥2分或运动项评分较基线增加≥1分分为进展性卒中组和非进展性卒中组，利用单因素分析两组患者的基线资料及SII和MHR，并采用多因素Logistic回归分析对影响急性期发生进展的独立相关因素进行分析，应用受试者工作特征(ROC)曲线分析SII联合MHR对ICAS相关缺血性卒中急性期发生进展的预测价值。结果:在280例急性缺血性卒中患者中，发生进展的有49例，未发生进展的有231例。多因素Logistic回归表明，SII(OR=1。005，95％CI:1。003-1。007，P＜0。001)及 MHR(OR=2。134，95％CI:1。512-3。012，P＜0。001)、NIHSS 评分(OR=1。240，95％CI:1。106-1。391，P＜0。001)均是 ICAS 相关缺血性卒中急性期发生进展的独立危险因素，且ROC曲线分析显示Sn联合MHR预测价值最大，曲线下面积为0。857(95％CI:0。810-0。0。895，P＜0。001)，最佳截断值为0。29，敏感度为67。3％，特异度为91。8％。结论:Sn联合MHR对ICAS相关缺血性卒中急性期进展有良好的预测价值。

外文标题：Predictive Value of Systemic Immune Inflammation Index Combined with Monocyte High Density Lipoprotein Ratio for Acute Phase Progression of ICAS-related Ischemic Stroke

外文摘要：Objective:To investigate the predictive value of systemic immunoinflammatory index(SII)combined with monocyte high density lipoprotein ratio(MHR)for acute progression of intracranial atherosclerosis(ICAS)related ischemic stroke.Methods:A total of 280 patients with acute ICAS-related stroke admitted to the Affiliated Hospital of Xuzhou Medical University from January 2021 to July 2023 were retrospectively collected and divided into progressive stroke group and non-progressive stroke group according to the NIHSS score(increased by ≥2 points)or exercise score(increased by ≥ 1 point from baseline)within 7 days of onset.Univariate analysis was performed on baseline data,SII and MHR between the two groups,and multivariate Logistic regression analysis was used to analyze the independent correlation factors affecting the progression of acute phase.The predictive value of SII combined with MHR in the pro-gression of acute phase of ICAS-related ischemic stroke was analyzed by receiver operating characteristics(ROC)curve.Results:Among 280 patients with acute ischemic stroke,with 49 cases progression in acute stage and 231 cases of no progression.Multivariate Logistic regression showed that SII(OR=1.005,95％CI:1.003-1.007,P＜0.001)and MHR(OR=2.134,95％CI:1.512-3.012,P＜0.001),NIHSS score(OR=1.240,95％CI:1.106-1.391,P＜0.001)were independent risk factors for the progression of ICAS-related ischemic stroke in the acute phase,and ROC curve analysis showed that SII combined with MHR had the greatest predictive value,0.857(95％CI:0.810-0.0.895,P＜0.001),the best cut-off value was 0.29,the sensitivity was 67.3％,and the specificity was 91.8％.Conclusion:SII com-bined with MHR has a good predictive value for the progression of ICAS-related ischemic stroke in acute stage.

外文关键词：

Monocyte high density lipoprotein ratio(MHR)Systemic immunoinflammatory index(SII)Intracranial Atherosclerosis(ICAS)ICAS-related ischemic strokeAcute ischemic stroke(AIS)Progressive stroke

作者：

刘彤彤、孔德莲、张卫、胡莹、张慈、时宏娟、花放

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作者单位：

徐州医科大学第一临床医学院江苏徐州 221000

南京市江宁医院江苏南京 211100

徐州医科大学附属医院神经内科江苏徐州 221000

美国奥古斯塔大学联合健康科学学院跨学科健康科学系美国30912

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关键词：

单核细胞高密度脂蛋白比值(MHR) 全身免疫炎症指数(SII) 颅内动脉粥样硬化性狭窄(ICAS) ICAS相关缺血性卒中急性缺血性卒中(AIS) 进展性卒中

出版年：

2024

DOI：

10.13241/j.cnki.pmb.2024.21.021

现代生物医学进展

黑龙江省森工总医院哈尔滨医科大学附属第四医院

现代生物医学进展

CSTPCD

影响因子：0.755

ISSN：1673-6273

年,卷(期)：2024.24(21)