Effect of HIFU Combined with Leuprorelin Acetate Sustained-release Microspheres Injection in the Treatment of Adenomyosis
Objective:To explore the effect of high-intensity focused ultrasound(HIFU)combined with subcutaneous injection of leuprorelin acetate sustained-release microspheres in the treatment of patients with adenomyosis(AM).Methods:According to the ran-dom number table method,220 patients with AM admitted to Deyang People's Hospital from June 2021 to June 2023 were divided into the control group and the observation group,with 110 cases in each group.The control group was treated with HIFU ablation,while the observation group was treated with subcutaneous injection of leuprorelin acetate sustained-release microspheres on the first day of men-struation on the basis of the treatment of control group.Lesion volume,degree of dysmenorrhea,menstrual volume,serum sex hormones[luteinizing hormone(LH),follicle-stimulating hormone(FSH)and estradiol(E2)],and the incidence rates of adverse reactions such as dizziness and nausea,abdominal pain and breast pain were compared between the two groups.Results:After 3 and 6 months of treat-ment,the lesion volume,VAS scores and pictorial blood assessment chart(PBAC)scores in both groups were decreased(P＜0.05),and lesion volume of the observation group was smaller than that of the control group,the observation group had lower VAS scores and PBAC scores than the control group(P＜0.05).After treatment,serum LH,FSH and E2 levels in both groups decreased,and the levels in observation group were lower than those in the control group(P＜0.05).The incidence of complications in the observation group was 5.45％,lower than 9.09％in the control group(P=0.299).Conclusion:HIFU combined with combined with leuprorelin acetate sus-tained-release microspheres injection is effective in the treatment of patients with AM,which can significantly reduce VAS score and PBAC score,improve serum hormone levels,and reduce the incidence of complications.
AdenomyosisHigh-intensity focused ultrasoundEfficacySerum sex hormoneMenstrual volume
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