Study on the Relationship between CXCL1,CXCL2 Expression and Epithelial Mesenchymal Transition and Prognosis in Non-Small Cell Lung Cancer Tissues
Objective:To investigate the relationship between the expression of C-X-C motif chemokine ligand(CXCL)1 and CXCL2 in non-small cell lung cancer(NSCLC)tissues and epithelial mesenchymal transition(EMT)and prognosis.Methods:241 NSCLC patients were selected,the positive expression rates of CXCL1,CXCL2 and EMT-related proteins[Vimentin(Vimentin),snail family transcription inhibitor 1(SNAI1),E-cadherin(E-cadherin),and N-cadherin(N-cadherin)]in NSCLC tissues and adjacent tissues(＞3 cm from NSCLC tissue)were detected by immunohistochemistry.The correlation between CXCL1,CXCL2 expression and expression of EMT-related proteins in NSCLC tissues were analyzed.To compare the difference of CXCL1 and CXCL2 positive expression in NSCLC tissues in patients with different clinicopathological features.3 years after follow-up,the 3-year overall survival(OS)rate was recorded.Results:Compared with adjacent tissues,the positive expression rates of CXCL1,CXCL2,Vimentin,SNAI1 and N-cadherin in NSCLC tissues were increased,and the positive expression rate of E-cadherin was decreased(P＜0.05).The expression of CXCL1 and CXCL2 in NSCLC tissues were related to TNM stage,tumor diameter,degree of differentiation and lymph node metastasis(P＜0.05).Followed-up for 3 years,the 3-year OS rate of 241 NSCLC patients was 56.02％(135/241).The 3-year OS rate of CXCL1 and CXCL2 positive expression in NSCLC patients was lower than that of CXCL1 and CXCL2 negative expression.(P＜0.05).The independent risk factors for death in NSCLC patients were TNM stage ⅢA,tumor diameter ≥ 3 cm,poor differentiation,CXCL1 positive,lymph node metastasis and CXCL2 positive(P＜0.05).Conclusion:The high expression of CXCL1 and CXCL2 in NSCLC tissues are related to TNM stage,tumor diameter,degree of differentiation,lymph node metastasis,EMT and prognosis,which may become a new target for the diagnosis and treatment of NSCLC.
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