摘要
目的:探讨脑梗死患者阿替普酶静脉溶栓治疗前后血清抗磷脂抗体(APA)、同型半胱氨酸(Hcy)、载脂蛋白(apo)-C3、apo-B变化及预后影响因素分析.方法:2021年1月至2023年1月期间在我院接受治疗的80例脑梗死患者,比较各组指标以及分析预后影响因素.结果:治疗后Hcy、apoC3、apo-B水平低于治疗前(P＜0.05);预后良好组与预后不良组患者年龄、溶栓前神经功能缺损量表(Neurological Deficiency Scale,NIHSS)评分、起病到溶栓时间、合并高血压、合并糖尿病、合并脑白质病变、合并脑萎缩、合并脑水肿情况、APA阳性率、Hcy、apoC3、apo-B水平对比差异显著(P＜0.05);年龄、溶栓前NIHSS评分、合并脑水肿、APA阳性率、Hcy、apoC3、apo-B为预后独立影响因素(P＜0.05).结论:阿替普酶溶栓治疗前后同型半胱氨酸及载脂蛋白明显改变,且年龄、溶栓前NIHSS评分、合并脑水肿、APA阳性率、Hcy、apoC3、apo-B是影响脑梗死的预后独立危险因素.
Abstract
Objective:To explore the changes of serum antiphospholipid antibody(APA),homocysteine(Hcy),apolipoprotein(apo)-C3,apo-B and the influencing factors before and after intravenous thrombolytic therapy in patients with cerebral infarction.Meth-ods:80 patients with cerebral infarction treated from January 2021 to January 2023 compared the indicators and analyzed the prognostic factors.Results:The levels of Hcy,apoC3,and apo-B were lower than those before treatment(P＜0.05);Patient Age and pre-thrombolysis Neurologic Defects Scale(Neurological Deficiency Scale,NIHSS)score,time from onset to thrombolysis,hypertension,diabetes,white matter lesions,cerebral atrophy,cerebral edema,APA positive rate,Hcy,apoC 3,and apo-B levels varied significantly(P＜0.05);Age,pre-thrombolysis NIHSS score,combined cerebral edema,APA positive rate,Hcy,apoC3,and apo-B were independent prognostic fac-tors(P＜0.05).Conclusion:Homocysteine and apolipoprotein were significantly changed before and after alteplase thrombolytic therapy,and age,NIHSS score before thrombolysis,combined cerebral edema,APA positive rate,Hcy,apoC 3 and apo-B were independent prog-nostic risk factors for cerebral infarction.
NETL
NSTL
万方数据