Analysis of Changes in Serum Antiphospholipid Antibodies,Homocysteine,and Apolipoprotein Levels and Prognostic Factors in Patients with Cerebral Infarction before and after Intravenous Thrombolysis with Ateplase
Objective:To explore the changes of serum antiphospholipid antibody(APA),homocysteine(Hcy),apolipoprotein(apo)-C3,apo-B and the influencing factors before and after intravenous thrombolytic therapy in patients with cerebral infarction.Meth-ods:80 patients with cerebral infarction treated from January 2021 to January 2023 compared the indicators and analyzed the prognostic factors.Results:The levels of Hcy,apoC3,and apo-B were lower than those before treatment(P＜0.05);Patient Age and pre-thrombolysis Neurologic Defects Scale(Neurological Deficiency Scale,NIHSS)score,time from onset to thrombolysis,hypertension,diabetes,white matter lesions,cerebral atrophy,cerebral edema,APA positive rate,Hcy,apoC 3,and apo-B levels varied significantly(P＜0.05);Age,pre-thrombolysis NIHSS score,combined cerebral edema,APA positive rate,Hcy,apoC3,and apo-B were independent prognostic fac-tors(P＜0.05).Conclusion:Homocysteine and apolipoprotein were significantly changed before and after alteplase thrombolytic therapy,and age,NIHSS score before thrombolysis,combined cerebral edema,APA positive rate,Hcy,apoC 3 and apo-B were independent prog-nostic risk factors for cerebral infarction.
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