Effects of Kunxian Capsules Combined with Methotrexate on Disease Activity Factors,Bone Metabolism Indexes and Th17 Cells in Rheumatoid Arthritis Patients
Objective:To observe the effects of kunxian capsules combined with methotrexate on disease activity factors,bone metabolism indexes and helper T(Th)17 cells in rheumatoid arthritis(RA)patients.Methods:From 152 RA patients were divided into control group(methotrexate treatment,76 cases)and study group(Kunxian capsule combined with methotrexate treatment,76 cases)by random number table method.The clinical efficacy,disease activity factors[C-reactive protein(CRP),rheumatoid factor(RF),erythro-cyte sedimentation rate(ESR)],bone metabolism indexes[osteoprotegerin(OPG),receptor activator of nuclear factor-KB ligand(RAN-KL)]and Th17 cells[peripheral blood Th17 cell ratio,interleukin(IL)-22,IL-17]were compared between two groups,and the safety in two groups was observed.Results:Compared with control group after treatment,the total effective rate in study group was higher,CRP,RF,ESR,RANKL,Th17 cell ratio,IL-17,IL-22 decreased more,OPG increased more(P＜0.05).There was no difference in the incidence of adverse reactions between two groups(P＞0.05).Conclusion:Kunxian capsules combined with methotrexate in the treatment of RA patients,which can improve the therapeutic effect by controlling disease activity factors,regulating bone metabolism indexes and Th17 cells,and has good safety.
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