Effects of Dexmedetomidine Combined with Propofol on Stress Response,Reproductive Hormones and Serum NGF,NSE and S100β Protein in Patients Undergoing Transurethral Resection of Prostate
Objective:To observe the effects of dexmedetomidine combined with propofol on stress response,reproductive hor-mones,serum nerve growth factor(NGF),neuron-specific enolase(NSE)and S100β protein in patients undergoing transurethral resec-tion of prostate(TURP).Methods:160 TURP patients were divided into control group(80 cases,propofol anesthesia)and observation group(80 cases,dexmedetomidine combined with propofol anesthesia)according to random number table method.The perioperative in-dexes,serum stress response indexes,reproductive hormones,incidence of postoperative delirium,serum NGF,NSE,S100β protein and adverse reactions were compared between two groups.Results:Compared with control group,first time out of bed,recovery time,hospi-talization time and first feeding time in observation group were shorter,and the incidence of postoperative delirium was lower(P＜0.05).Compared with control group 1 d after operation,epinephrine(NE),cortisol(Cor),testosterone(T),estrogen(E2),follicle stimulating hor-mone(FSH),luteinizing hormone(LH),NSE,S100β protein in observation group were lower,and NGF was higher(P＜0.05).The inci-dence of adverse reactions:There was no difference between the control group of 6.25％and the observation group of 5.00％(P＞0.05).Conclusion:The combination of dexmedetomidine and propofol can reduce the stress response,reduce the level of the incidence of post-operative delirium,improve reproductive hormones levels and regulate the levels of serum NGF,NSE and S100β protein in TURP patients,and with good safety.
DexmedetomidinePropofolTransurethral resection of the prostateStress responseReproductive hormonesNerve growth factorNeuron-specific enolaseS100β protein
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