Effects of Flurbiprofen Axetil Combined with Posterior Quadratus Lumborum Block on Analgesic Effect,Stress State and Pain Factors in Patients Undergoing Laparoscopic Radical Resection of Colon Cancer
Objective:To investigate the analgesic effect,stress state and pain factors changes of patients undergoing laparoscopic radical resection of colon cancer(COAD)during anesthesia using flurbiprofen axetil combined with posterior quadratus lumborum block(QLB).Methods:138 patients undergoing COAD radical operation were divided into control group(QLB treatment,n=69)and observa-tion group(flurbiprofen axetil combined with QLB treatment,n=69)according to the random number table method.The postoperative re-covery indexes,stress indexes and pain factors were compared between the two groups,and the adverse reactions btween two groups were recorded.Results:The first time of getting out of bed,the first exhaust time and the first defecation time in observation group were shorter than those in control group(P＜0.05).The β-endorphin(β-EP)in observation group was higher than that in control group at 1 d after operation,and prostaglandin E2(PGE2),substance P(SP),cortisol(Cor),epinephrine(E)and norepinephrine(NE)were lower than those in control group(P＜0.05).There was no difference in the incidence of adverse reactions between the two groups(P＞0.05).Conclu-sion:Flurbiprofen axetil combined with QLB for patients undergoing COAD radical resection,can reduce the level of pain factors and re-duce postoperative pain,which is conducive to early postoperative recovery.
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