Relationship between Serum HO-1,ESM-1 and Coronary Artery Disease and Major Adverse Cardiovascular Events in Patients with Acute ST-Segment Elevation Myocardial Infarction Combined with Type 2 Diabetes Mellitus
Objective:To investigate the relationship between serum heme oxygenase-1(HO-1),endothelial cell specific molecule-1(ESM-1)and coronary artery disease and major adverse cardiovascular events(MACE)in patients with acute ST-segment elevation myocardial infarction(ASTEMI)combined with type 2 diabetes mellitus(T2DM).Methods:177 patients with ASTEMI com-bine with T2DM(T2DM group)who underwent percutaneous coronary intervention were selected,90 ASTEMI patients without T2DM(non-T2DM group)and 90 healthy subjects(control group)were selected.patients with ASTEMI combine with T2DM were divided into 73 cases of mild coronary artery disease group,63 cases of moderate coronary artery disease group and 41 cases of severe coronary artery disease group according to Gensini score,and patients were divided into MACE group(63 cases)and non-MACE group(114 cases)according to whether MACE occurred 6 months after percutaneous coronary intervention.The occurrence of MACE in patients with ASTEMI combine with T2DM as the dependent variable,multivariate Logistic regression model was established to determine the influ-encing factors.Results:The levels of serum HO-1 and ESM-1 in T2DM group were higher than those in non-T2DM group and healthy control group(P＜0.05).The levels of serum HO-1 and ESM-1 in mild,moderate and severe coronary artery disease groups increased in turn(P＜0.05).After 6 months of follow-up,the incidence of MACE after PCI in 177 patients with ASTEMI combine with T2DM was 35.59％(63/177).The independent risk factors of MACE in patients with ASTEMI combined with T2DM were KILLIP grade ≥ Ⅱ,high Gensini score,high HO-1 and high ESM-1(P＜0.05).Conclusion:The increase of serum HO-1 and ESM-1 levels is relate to the aggrava-tion of coronary artery disease and the occurrence of MACE in patients with ASTEMI combine with T2DM.
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