Exploring the Effect of Xingnaojing Injection Combined with Nimodipine on the Recovery of Neurological Function in Patients with Hypertensive Intracerebral Hemorrhage Based on SDF-1/CXCR4 Signaling Pathway
Objective:Based on the stromal cell-derived factor-1(SDF-1)/CXC chemokine receptor 4(CXCR4)signaling path-way,to investigate the effect of xingnaojing injection combined with nimodipine on the recovery of neurological function in patients with hypertensive intracerebral hemorrhage(HICH).Methods:Using a random number table method,132 patients with HICH were divided into control group(treated with nimodipine,66 cases)and research group(treated with xingnaojing injection on the basis of control group,66 cases).The changes of serum nerve cell factor indexes,serum SDF-1,CXCR4 levels,quality of life disease scale(SIS)score,national institutes of health stroke scale(NIHSS)score and modified Rankin scale(mRS)score were compared in two groups.Results:After 14 days of treatment,the levels of serum neuron-specific enolase(NSE),myelin basic protein(MBP),glial fibrillary acidic protein(GFAP),SDF-1 and CXCR4 in two groups decreased,and the decrease was more significant in the research group(P＜0.05).After 3 months of treatment,the NIHSS and mRS scores in two groups decreased,and research group improved more significantly(P＜0.05).The scores of SIS in each dimension in two groups increased,and research group improved more significantly(P＜0.05).Conclusion:Xingnao-jing injection combined with nimodipine can significantly improve the prognosis of HICH patients,and promote the recovery of neuro-logical function,the mechanism may be related to the regulation of SDF-1/CXCR4 signaling pathway.
Hypertensive intracerebral hemorrhageSDF-1/CXCR4 signaling pathwayXingnaojing injectionNimodipineNeuro-logical function
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