Effect of Yishen Ovulation-Promoting Decoction Combined with Letrozole on Endocrine Level,Ovarian Function and Serum Ghrelin,AMH and NF-κB in Patients with PCOS Infertility
Objective:To investigate the effects of letrozole combined with yishen ovulation-promoting decoction on ovarian function,endocrine level,serum growth hormone releasing peptide(Ghrelin),anti-Mullerian hormone(AMH)and nuclear transcription factor-KB(NF-κB)in patients with polycystic ovary syndrome(PCOS)infertility.Methods:Patients with PCOS infertility(132 cases)in our hospital were randomly divided into control group(66 cases,letrozole treatment)and experimental group(66 cases,letrozole,yishen ovulation-promoting decoction combined treatment).Endocrine indexes,ovarian function indexes,serum Ghrelin,AMH,NF-κB levels,ovulation and pregnancy were compared between two groups.Results:Compared with control group after treatment,basic luteinizing hormone(LH),pulsatility index,resistance index,NF-κB,AMH in experimental group were lower,and mid-luteal estradiol(E2),mid-luteal progesterone(P),endometrial thickness,Ghrelin were higher(P＜0.05).Six months after follow-up,the ovulation rate and pregnancy rate in experimental group were higher than those in control group(P＜0.05).Conclusion:Letrozole combined with yishen ovulation-promoting decoction in the treatment of PCOS infertility patients,which can effectively improve the endocrine level,ovarian function,serum Ghrelin,AMH and NF-κB levels,and improve the pregnancy rate and ovulation rate.
NETL
NSTL
万方数据
