摘要
目的:探讨多囊卵巢综合征(PCOS)不孕症采用来曲唑、益肾促排卵汤联合治疗后,对患者卵巢功能、内分泌水平、血清生长激素释放肽(Ghrelin)、抗苗勒管激素(AMH)、核转录因子κB(NF-κB)的影响.方法:将我院PCOS不孕症患者(132例)随机分为对照组(66例,来曲唑治疗)和试验组(66例,来曲唑、益肾促排卵汤联合治疗).对比两组内分泌指标、卵巢功能指标、血清Ghre-lin、AMH、NF-κB水平、排卵及妊娠情况.结果:与对照组治疗后相比,试验组基础促黄体生成素(LH)、搏动指数、阻力指数、NF-κB、AMH更低,黄体中期雌二醇(E2)、黄体中期孕酮(P)、子宫内膜厚度、Ghrelin更高(P＜0.05).随访六个月后,试验组的排卵率、妊娠率高于对照组(P＜0.05).结论:PCOS不孕症采用来曲唑、益肾促排卵汤联合治疗后,可有效改善患者内分泌水平、卵巢功能及血清Ghrelin、AMH、NF-κB水平,提高妊娠率和排卵率.
Abstract
Objective:To investigate the effects of letrozole combined with yishen ovulation-promoting decoction on ovarian function,endocrine level,serum growth hormone releasing peptide(Ghrelin),anti-Mullerian hormone(AMH)and nuclear transcription factor-KB(NF-κB)in patients with polycystic ovary syndrome(PCOS)infertility.Methods:Patients with PCOS infertility(132 cases)in our hospital were randomly divided into control group(66 cases,letrozole treatment)and experimental group(66 cases,letrozole,yishen ovulation-promoting decoction combined treatment).Endocrine indexes,ovarian function indexes,serum Ghrelin,AMH,NF-κB levels,ovulation and pregnancy were compared between two groups.Results:Compared with control group after treatment,basic luteinizing hormone(LH),pulsatility index,resistance index,NF-κB,AMH in experimental group were lower,and mid-luteal estradiol(E2),mid-luteal progesterone(P),endometrial thickness,Ghrelin were higher(P＜0.05).Six months after follow-up,the ovulation rate and pregnancy rate in experimental group were higher than those in control group(P＜0.05).Conclusion:Letrozole combined with yishen ovulation-promoting decoction in the treatment of PCOS infertility patients,which can effectively improve the endocrine level,ovarian function,serum Ghrelin,AMH and NF-κB levels,and improve the pregnancy rate and ovulation rate.
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