Effects of Jiawei Shaogan Fuzi Decoction Combined with Mild Moxibustion on Immune Function and Serum IL-1β,IL-6 and IL-18 in Patients with Active Rheumatoid Arthritis of Cold-Dampness Obstruction Type
Objective:To observe the combined treatment of jiawei shaogan fuzi decoction and mild moxibustion in patients with active rheumatoid arthritis(RA)of cold-dampness obstruction type,the effects on immune function and serum interleukin(IL)-1β,IL-6,IL-18.Methods:142 patients with active RA(cold-dampness obstruction type)were divided into control group(mild moxibustion treat-ment,n=71)and combine group(Jiawei Shaogan Fuzi Decoction combine with mild moxibustion treatment,n=71)according to the ran-dom number table method.The efficacy,laboratory indexes,immune function and serum inflammatory factors were compared between two groups.Results:Compared with control group,the total clinical effective rate in combine group was significantly higher(P＜0.05).Compared with control group after treatment,rheumatoid factor(RF),erythrocyte sedimentation rate(ESR),C-reactive protein(CRP),im-munoglobulin G(IgG),immunoglobulin G(IgA),immunoglobulin M(IgM),IL-1β,IL-6 and IL-18 in combine group were lower(P＜0.05).Conclusion:Jiawei shaogan fuzi decoction combined with mild moxibustion can improve clinical treatment effect,regulate immune func-tion and inhibit serum IL-1β,IL-6 and IL-18 levels in patients with active RA of cold-dampness obstruction type.
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