加味芍甘附子汤联合温和灸对寒湿痹阻型活动期类风湿关节炎患者免疫功能和血清IL-1β、IL-6、IL-18的影响
Effects of Jiawei Shaogan Fuzi Decoction Combined with Mild Moxibustion on Immune Function and Serum IL-1β,IL-6 and IL-18 in Patients with Active Rheumatoid Arthritis of Cold-Dampness Obstruction Type
刘亚伟 1马俊福 2谷慧敏 2杨双庆 1李玉洁 1李锦锦1
作者信息
- 1. 河南中医药大学骨伤学院 河南郑州 450046
- 2. 河南省中医院风湿病科 河南郑州 450002
- 折叠
摘要
目的:观察加味芍甘附子汤、温和灸联合治疗寒湿痹阻型活动期类风湿关节炎(RA)患者,对免疫功能和血清白细胞介素(IL)-1β、IL-6、IL-18的影响.方法:选取142例活动期RA患者(寒湿痹阻型)按随机数字表法分为对照组(温和灸治疗,n=71)和b联合组(加味芍甘附子汤联合温和灸治疗,n=71).对比两组疗效、实验室指标、免疫功能和血清炎症因子.结果:与对照组相比,联合组的临床总有效率明显升高(P＜0.05).与对照组治疗后相比,联合组的类风湿因子(RF)、血沉(ESR)、C反应蛋白(CRP)、免疫球蛋白G(IgG)、免疫球蛋白G(IgA)、免疫球蛋白M(IgM)、IL-1β、IL-6、IL-18更低(P＜0.05).结论:加味芍甘附子汤联合温和灸治疗寒湿痹阻型活动期RA患者,可提高临床治疗效果,调节免疫功能和抑制血清IL-1β、IL-6、IL-18水平.
Abstract
Objective:To observe the combined treatment of jiawei shaogan fuzi decoction and mild moxibustion in patients with active rheumatoid arthritis(RA)of cold-dampness obstruction type,the effects on immune function and serum interleukin(IL)-1β,IL-6,IL-18.Methods:142 patients with active RA(cold-dampness obstruction type)were divided into control group(mild moxibustion treat-ment,n=71)and combine group(Jiawei Shaogan Fuzi Decoction combine with mild moxibustion treatment,n=71)according to the ran-dom number table method.The efficacy,laboratory indexes,immune function and serum inflammatory factors were compared between two groups.Results:Compared with control group,the total clinical effective rate in combine group was significantly higher(P＜0.05).Compared with control group after treatment,rheumatoid factor(RF),erythrocyte sedimentation rate(ESR),C-reactive protein(CRP),im-munoglobulin G(IgG),immunoglobulin G(IgA),immunoglobulin M(IgM),IL-1β,IL-6 and IL-18 in combine group were lower(P＜0.05).Conclusion:Jiawei shaogan fuzi decoction combined with mild moxibustion can improve clinical treatment effect,regulate immune func-tion and inhibit serum IL-1β,IL-6 and IL-18 levels in patients with active RA of cold-dampness obstruction type.
关键词
加味芍甘附子汤/活动期/温和灸/寒湿痹阻型/免疫功能/IL-1β/IL-6/IL-18/类风湿关节炎Key words
Jiawei shaogan fuzi decoction/Active stage/Mild moxibustion/Cold-dampness obstruction type/Immune function/IL-1β/IL-6/IL-18/Rheumatoid arthritis引用本文复制引用
出版年
2024
NETL
NSTL
万方数据